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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
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- 1 - 11 (11page)
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Background: We aimed to compare the therapeutic efficacy of prolonged macrolide (PMC), corticosteroids (CST), doxycycline (DXC), and levofloxacin (LFX) against macrolide- unresponsive Mycoplasma pneumoniae (MP) pneumonia in children and to evaluate the safety of the secondary treatment agents. Methods: We retrospectively analyzed the data of patients with MP pneumonia hospitalized between January 2015 and April 2017. Macrolide-unresponsiveness was clinically defined with a persistent fever of ≥ 38.0°C at ≥ 72 hours after macrolide treatment. The cases were divided into four groups: PMC, CST, DXC, and LFX. We compared the time to defervescence (TTD) after secondary treatment and the TTD after initial macrolide treatment in each group with adjustment using propensity score-matching analysis. Results: Among 1,165 cases of MP pneumonia, 190 (16.3%) were unresponsive to macrolides. The proportion of patients who achieved defervescence within 48 hours in CST, DXC, and LFX groups were 96.9% (31/33), 85.7% (12/14), and 83.3% (5/6), respectively. The TTD after initial macrolide treatment did not differ between PMC and CST groups (5.1 vs. 4.2 days, P = 0.085), PMC and DXC groups (4.9 vs. 5.7 days, P = 0.453), and PMC and LFX groups (4.4 vs. 5.0 days, P = 0.283). No side effects were observed in the CST, DXC, and LFX groups. Conclusion: The change to secondary treatment did not show better efficacy compared to PMC in children with macrolide-unresponsive MP pneumonia. Further studies are needed to guide appropriate treatment in children with MP pneumonia.
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참고문헌 (35)
참고문헌 신청
Narita M / 2010 / Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia / J Infect Chemother 16(3):162~169
You-Sook Youn / 2012 / Mycoplasma pneumoniae pneumonia in children / Korean Journal of Pediatrics 55(2):42~47
Atkinson TP / 2008 / Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections / FEMS Microbiol Rev 32(6):956~973
Eun BW / 2008 / Mycoplasma pneumoniae in Korean children: the epidemiology of pneumonia over an 18-year period / J Infect 56(5):326~331
김은경 / 2015 / Epidemiological comparison of three Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years / Korean Journal of Pediatrics 58(5):172~177
You-Sook Youn / 2012 / Mycoplasma pneumoniae pneumonia in children / Korean Journal of Pediatrics 55(2):42~47
Atkinson TP / 2008 / Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections / FEMS Microbiol Rev 32(6):956~973
Eun BW / 2008 / Mycoplasma pneumoniae in Korean children: the epidemiology of pneumonia over an 18-year period / J Infect 56(5):326~331
김은경 / 2015 / Epidemiological comparison of three Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years / Korean Journal of Pediatrics 58(5):172~177
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