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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 577 - 594 (18page)
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In higher eukaryotes, proteomes are typically larger than corresponding genomes mostly due to alternative spicing (AS) which is affecting more than 86 % of human genes. Tissue specificity of many proteins is often determined by the AS of pre-mRNAs that generates multiple proteins from a single gene. Aberrations in AS are found in numerous human diseases. This article shows that AS expanded the classic ‘‘one-gene–one-protein’’ paradigm to the ‘‘one-gene–many-proteins’’ concept. AS is intimately associated with protein intrinsic disorder. There is a tight connection between the altered AS of some key intrinsically disordered proteins and pathogenesis of neurodegenerative diseases, cardiovascular disease, cancer, and diabetes. The development of drugs for splice variants is a challenging endeavor. AS has tremendous influence on the applicability of several drugs developed to affect functions typically attributed to the ordered parts of disease- related proteins. Although there are several means for the differential targeting of splice variants, new approaches are obviously needed. It is expected that better understanding of the molecular mechanisms underlying modulation of biological activities of numerous spliced variants will be achieved and new drug design approaches for proteins with multiple splice variants will be developed.
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참고문헌 (177)
참고문헌 신청
Adamia S / 2013 / Alternative splicing in chronic myeloid leukemia (CML): a novel therapeutic target / Curr Cancer Drug Targets 13:735~748
Adamia S / 2014 / A Genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets / Clin Cancer Res 20:1135~1145
Anderson CW / 2004 / Handbook of cell signaling / Academic Press :237~247
Andreadis A / 2012 / Tau splicing and the intricacies of dementia / J Cell Physiol 227:1220~1225
Bahn JH / 2012 / Accurate identification of A-to-I RNA editing in human by transcriptome sequencing / Genome Res 22:142~150
Adamia S / 2014 / A Genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets / Clin Cancer Res 20:1135~1145
Anderson CW / 2004 / Handbook of cell signaling / Academic Press :237~247
Andreadis A / 2012 / Tau splicing and the intricacies of dementia / J Cell Physiol 227:1220~1225
Bahn JH / 2012 / Accurate identification of A-to-I RNA editing in human by transcriptome sequencing / Genome Res 22:142~150
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