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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 316 - 325 (10page)
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The morbidity and mortality associated with diabetic complications impose a huge socioeconomic burden worldwide. Therefore, the ultimate goal of managing diabetes mellitus (DM) is to lower the risk of macrovascular complications and highly morbid microvascular complications such as diabetic nephropathy (DN) and diabetic retinopathy (DR). Potential benefits of incretin-based therapies such as glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors on the diabetic macrovascular complications have been recently suggested, owing to their pleiotropic effects on multiple organ systems. However, studies primarily investigating the role of these therapies in diabetic microvascular complications are rare. Nevertheless, preclinical and limited clinical data suggest the potential protective effect of incretin-based agents against DN and DR via their anti-inflammatory, antioxidative, and antiapoptotic properties. Evidence also suggests that these incretin-dependent and independent beneficial effects are not necessarily associated with the glucose-lowering properties of GLP-1 RAs and DPP-4 inhibitors. Hence, in this review, we revisit the preclinical and clinical evidence of incretin-based therapy for DR and DN, the two most common, morbid complications in individuals with DM. In addition, the review discusses a few recent studies raising concerns of aggravating DR with the use of incretin-based therapies.
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참고문헌 (64)
참고문헌 신청
UK Prospective Diabetes Study (UKPDS) Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
Holman RR / 2008 / 10-Year follow-up of intensive glucose control in type 2 diabetes / N Engl J Med 359:1577~1589
Korean Diabetes Association / Diabetes fact sheet in Korea 2016
Aroor AR / 2014 / Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system / Am J Physiol Heart Circ Physiol 307:H477~H492
Fava S / 2014 / Glucagon-like peptide 1 and the cardiovascular system / Curr Diabetes Rev 10:302~310
Holman RR / 2008 / 10-Year follow-up of intensive glucose control in type 2 diabetes / N Engl J Med 359:1577~1589
Korean Diabetes Association / Diabetes fact sheet in Korea 2016
Aroor AR / 2014 / Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system / Am J Physiol Heart Circ Physiol 307:H477~H492
Fava S / 2014 / Glucagon-like peptide 1 and the cardiovascular system / Curr Diabetes Rev 10:302~310
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