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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 147 - 158 (12page)
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초록· 키워드
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Diabetes is a common metabolic disorder with a worldwide prevalence of 8.3% and is the leading cause of visual loss, end-stage renal disease and amputation. Recently, genome-wide association studies (GWASs) have identified genetic risk factors for diabetic microvascular complications of retinopathy, nephropathy, and neuropathy. We summarized the recent findings of GWASs on diabetic microvascular complications and highlighted the challenges and our opinion on future directives. Five GWASs were conducted on diabetic retinopathy, nine on nephropathy, and one on neuropathic pain. The majority of recent GWASs were underpowered and heterogeneous in terms of study design, inclusion criteria and phenotype definition. Therefore, few reached the genome-wide significance threshold and the findings were inconsistent across the studies. Recent GWASs provided novel information on genetic risk factors and the possible pathophysiology of diabetic microvascular complications. However, further collaborative efforts to standardize phenotype definition and increase sample size are necessary for successful genetic studies on diabetic microvascular complications.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Korean Diabetes Association / Diabetes Fact Sheet in Korea 2013
진동찬 / 2014 / Renal replacement therapy in Korea, 2012 / Kidney Research and Clinical Practice 33(1):9~18
UK Prospective Diabetes Study (UKPDS) Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
ACCORD Study Group / 2010 / Effects of medical therapies on retinopathy progression in type 2 diabetes / N Engl J Med 363:233~244
Ismail-Beigi F / 2010 / Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial / Lancet 376:419~430
진동찬 / 2014 / Renal replacement therapy in Korea, 2012 / Kidney Research and Clinical Practice 33(1):9~18
UK Prospective Diabetes Study (UKPDS) Group / 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) / Lancet 352:837~853
ACCORD Study Group / 2010 / Effects of medical therapies on retinopathy progression in type 2 diabetes / N Engl J Med 363:233~244
Ismail-Beigi F / 2010 / Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial / Lancet 376:419~430
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