지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 69 - 74 (6page)
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초록· 키워드
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Background The prevalence of type 2 diabetes mellitus (T2DM) and obesity is increasing in Korea. Clinical studies in patients with T2DM have shown that combining the glucagon-like peptide-1 receptor agonist exenatide twice daily with basal insulin is an effective glucose-lowering strategy. However, these studies were predominantly conducted in non-Asian populations. Methods We conducted a subgroup analysis of data from a multinational, 30-week, randomized, open-label trial to compare the effects of exenatide twice daily (n=10) or three times daily mealtime insulin lispro (n=13) among Korean patients with T2DM inadequately controlled (glycosylated hemoglobin [HbA1c] >7.0%) on metformin plus optimized insulin glargine. Results Exenatide twice daily and insulin lispro both reduced HbA1c (mean −1.5% and −1.0%, respectively; P<0.01 vs. baseline). Fasting glucose and weight numerically decreased with exenatide twice daily (−0.7 mmol/L and −0.7 kg, respectively) and numerically increased with insulin lispro (0.9 mmol/L and 1.0 kg, respectively). Minor hypoglycemia occurred in four patients receiving exenatide twice daily and three patients receiving insulin lispro. Gastrointestinal adverse events were the most common with exenatide twice daily treatment. Conclusion This analysis found treatment with exenatide twice daily improved glycemic control without weight gain in Korean patients with T2DM unable to achieve glycemic control on metformin plus basal insulin.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Chan JC / 2009 / Diabetes in Asia: epidemiology, risk factors, and pathophysiology / JAMA 301:2129~2140
김대중 / 2011 / The Epidemiology of Diabetes in Korea / Diabetes and Metabolism Journal 35(4):303~308
WHO Expert Consultation / 2004 / Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies / Lancet 363:157~163
김철식 / 2014 / Prevalence, Awareness, and Management of Obesity in Korea: Data from the Korea National Health and Nutrition Examination Survey (1998–2011) / Diabetes and Metabolism Journal 38(1):35~43
손장원 / 2015 / Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea / Diabetes and Metabolism Journal 39(5):387~394
김대중 / 2011 / The Epidemiology of Diabetes in Korea / Diabetes and Metabolism Journal 35(4):303~308
WHO Expert Consultation / 2004 / Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies / Lancet 363:157~163
김철식 / 2014 / Prevalence, Awareness, and Management of Obesity in Korea: Data from the Korea National Health and Nutrition Examination Survey (1998–2011) / Diabetes and Metabolism Journal 38(1):35~43
손장원 / 2015 / Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea / Diabetes and Metabolism Journal 39(5):387~394
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