Diagnosing Diabetic Neuropathy: Something Old, Something New

Ioannis N. Petropoulos; Georgios Ponirakis; Adnan Khan; Hamad Almuhannadi; Hoda Gad; Rayaz A. Malik

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자료유형: 학술저널

저자정보: Ioannis N. Petropoulos (Weill Cornell Medicine Qatar) Georgios Ponirakis (Weill Cornell Medicine Qatar) Adnan Khan (Weill Cornell Medicine Qatar) Hamad Almuhannadi (Weill Cornell Medicine Qatar) Hoda Gad (Weill Cornell Medicine Qatar) Rayaz A. Malik (Weill Cornell Medicine Qatar)

저널정보: 대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.42 No.4

발행연도: 2018.1

수록면: 255 - 269 (15page)

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There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess therapeutic benefit in clinical trials of DPN. Over the past several decades symptoms and signs, quantitative sensory and electrodiagnostic testing have been strongly endorsed, but have consistently failed as surrogate end points in clinical trials. Therefore, there is an unmet need for reliable biomarkers to capture the onset and progression and to facilitate drug discovery in DPN. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging modality for in vivo evaluation of sensory C-fibers. An increasing body of evidence from multiple centers worldwide suggests that CCM fulfills the FDA criteria as a surrogate endpoint of DPN.

참고문헌 (133)

참고문헌 신청

Baron R / 2010 / Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment / Lancet Neurol 9:807~819

Boulton AJ / 1998 / Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy / Diabet Med 15:508~514

Boulton AJ / 2004 / Diabetic somatic neuropathies / Diabetes Care 27:1458~1486

Spallone V / 2012 / Validation of DN4 as a screening tool for neuropathic pain in painful diabetic polyneuropathy / Diabet Med 29:578~585

Bennett M / 2001 / The LANSS pain scale: the Leeds Assessment of Neuropathic Symptoms and Signs / Pain 92:147~157

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