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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 92 - 100 (9page)
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Purpose: The hepatic resection is the gold-standard treatment for patients with colorectal-cancer liver metastases (CLM). This study aimed to identify prognostic factors in patients with synchronous CLM who underwent a surgical curative (R0) resection with respect to the number of metastatic nodules. Methods: Of 1,261 CLM patients treated between January 1991 and December 2010, 339 who underwent a R0 resection for synchronous CLM were included in this retrospective analysis. Patients were grouped according to the number of CLM nodules: 1–2 CLM nodules, n = 272 (group 1) and 3–8 CLM nodules, n = 67 (group 2). Results: The 5-year progression-free survival (PFS) rate in group 1was better than that in group 2 (P = 0.020). The multivariate analysis identified lymph-node metastasis (N2), lymphovascular invasion (LVI), and three or more CLM nodules as independent poor prognostic factors for PFS in all patients and lymph-node metastasis (N2) and LVI as independent poor prognostic factors for patients in group 1. No independent prognostic factors were identified for patients in group 2. CLM treatment method and neoadjuvant chemotherapy were not associated with survival. Conclusion: Three or more metastatic nodules, lymph-node metastasis (N2), and LVI were independent poor prognostic factors for PFS in patients with synchronous CLM who underwent a R0 resection. The latter 2 factors were also independent prognostic factors for PFS in patients with less than 3 CLM nodules; however, in patients with three or more CLM nodules, the prognosis for PFS may be related only to liver metastasis.
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참고문헌 (40)
참고문헌 신청
Kemeny N / 1999 / Arterial, portal, or systemic chemotherapy for patients with hepatic metastasis of colorectal carcinoma / J Hepatobiliary Pancreat Surg 6:39~49
Nathan H / 2010 / Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patients / J Am Coll Surg 210:755~764
Adam R / 2001 / Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal / Ann Surg Oncol 8:347~353
House MG / 2010 / Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution / J Am Coll Surg 210:744~752
Leonard GD / 2005 / Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma / J Clin Oncol 23:2038~2048
Nathan H / 2010 / Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patients / J Am Coll Surg 210:755~764
Adam R / 2001 / Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal / Ann Surg Oncol 8:347~353
House MG / 2010 / Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution / J Am Coll Surg 210:744~752
Leonard GD / 2005 / Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma / J Clin Oncol 23:2038~2048
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