Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer

Sare Hosseini; Ali Mohammad Bananzadeh; Roham Salek; Mohammad Zare-Bandamiri; Ali Taghizadeh Kermani; Mohammad Mohammadianpanah

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자료유형: 학술저널

저자정보: Sare Hosseini (Mashhad University) Ali Mohammad Bananzadeh (Shiraz University) Roham Salek (Shiraz University) Mohammad Zare-Bandamiri (Shiraz University) Ali Taghizadeh Kermani (Mashhad University) Mohammad Mohammadianpanah (Shiraz University)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.33 No.2

발행연도: 2017.1

수록면: 57 - 63 (7page)

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Purpose: Mucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer. Methods: This retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013. Results: Totally, 144 of 1,268 patients with a colorectal adenocarcinoma (11.4%) had mucinous histologic subtype. Statistically significant results found in this research are as follows: Mucinous histologic subtype tended to present in younger patients and to have larger tumor size, higher histologic grade, higher node stage, larger number of positive nodes, and higher rate of perineural invasion compared to nonmucinous histologic subtype. On the univariate analysis, mucinous subtype was a prognostic factor for disease-free and overall survival. On the multivariate analysis, primary tumor location, node stage and lymphatic-vascular invasion were independent prognostic factors for the local control rate. Rectal tumor location, higher disease stage, tumor grade II, and presence of lymphatic-vascular invasion had negative influences on disease-free survival, as did rectal tumor location, higher disease stage and presence of lymphatic-vascular invasion on overall survival. Conclusion: Mucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer; however, it was not an independent prognostic factor for oncologic outcome.

참고문헌 (31)

참고문헌 신청

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Kulendran M / 2011 / Predictive and prognostic factors in colorectal cancer: a personalized approach / Cancers (Basel) 3:1622~1638

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