Evaluation of Prognostic Factors for the Parotid Cancer Treated With Surgery and Postoperative Radiotherapy

김용협; 정웅기; 정재욱; 조익준; 윤미선; 송주영; 남택균; 안성자; 이동훈; 윤태미; 이준규; 임상철

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자료유형: 학술저널

저자정보: 김용협 정웅기 정재욱 조익준 윤미선 송주영 남택균 안성자 이동훈 윤태미 이준규 임상철

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제13권 제1호

발행연도: 2020.1

수록면: 69 - 76 (8page)

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Objectives. To investigate the prognostic factors and treatment outcomes of primary parotid carcinoma treated with surgery and postoperative radiotherapy (PORT). Methods. We reviewed retrospectively 57 patients with primary parotid carcinoma who were treated with surgery and PORT between 2005 and 2014. Superficial parotidectomy was performed in 19 patients, total parotidectomy in 10 patients, and total parotidectomy with lymph node dissection in 28 patients PORT on the tumor bed was performed in 41 patients, while PORT on tumor bed and ipsilateral cervical lymph nodes was performed in 16 patients. Results. With a median follow-up of 66 months, the 5-year overall survival, disease-free survival, locoregional control, and distant control rates were 77.0%, 60.2%, 77.6%, and 72.8%, respectively. The 5-year overall survival by stage was 100%, 100%, 80.0%, and 46.4% in stage I, II, III, and IV, respectively. Recurrences at primary lesions were found in seven patients, while at cervical nodes in six patients. Distant recurrences were developed in 12 patients. No patient with the low and intermediate histologic grade developed distant failure. As prognostic factors, the histologic grade for overall survival (P=0.005), pathological T-stage (P=0.009) and differentiation grade (P=0.009) for disease-free survival, pathological T-stage for locoregional control (P=0.007), and lympho-vascular invasion (P=0.023) for distant recurrence were significant on multivariate analysis. Conclusion. This study revealed that differentiation grade, histologic grade, pathological T-stage, and lympho-vascular invasion were significant independent prognostic factors on clinical outcomes.

참고문헌 (30)

참고문헌 신청

Calearo C / 1998 / Parotid gland carcinoma: analysis of prognostic factors / Ann Otol Rhinol Laryngol 107(11 Pt 1):969~973

Lewis AG / 2016 / Diagnosis and management of malignant salivary gland tumors of the parotid gland / Otolaryngol Clin North Am 49(2):343~380

Terhaard CH / 2004 / Salivary gland carcinoma : independent prognostic factors for locoregional control, distant metastases, and overall survival : results of the Dutch head and neck oncology cooperative group / Head Neck 26(8):681~692

Terhaard CH / 2005 / The role of radiotherapy in the treatment of malignant salivary gland tumors / Int J Radiat Oncol Biol Phys 61(1):103~111

Jeannon JP / 2009 / Management of advanced parotid cancer : a systematic review / Eur J Surg Oncol 35(9):908~915

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