지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 48 - 58 (11page)
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초록· 키워드
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Background and Objectives Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. Methods Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A standard case report form was used for clinical and echocardiographic parameters. Results Mean age at the time of AV surgery was 59±13 years. The most common cause of AV surgery was aortic stenosis (AS, 892 [77%]), followed by aortic regurgitation (AR, 199 [17%]), and infective endocarditis (69 [6%]). AS showed a skewed peak in the aged population and was the predominant cause of AV surgery (87%) in patients ≥50 years of age, whereas AR (46%) and active infective endocarditis (19%) were more common in younger patients (p<0.001). Echocardiographic determination of the BAV phenotype revealed that fusion of the right coronary cusp (RCC) and left coronary cusp (LCC) was most common (622 [53%]), followed by fusion of RCC and non-coronary cusp (NCC) (313 [27%]), and fusion of LCC and NCC (42 [4%]); the BAV phenotype could not be determined in the remaining 183 patients (16%). Fusion of RCC and LCC was more commonly observed in patients with AR than in those with AS (74% vs. 49%; p<0.001). Conclusion BAV patients were characterized by distinct surgical indications according to their age. Possible associations between BAV phenotypes and surgical indications with potential impacts of ethnicity need to be tested in further studies.
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참고문헌 (29)
참고문헌 신청
Hoffman JI / 2002 / The incidence of congenital heart disease / J Am Coll Cardiol 39:1890~1900
Roger VL / 2011 / Heart disease and stroke statistics--2011 update: a report from the American Heart Association / Circulation 123:e18~e209
Fedak PW / 2002 / Clinical and pathophysiological implications of a bicuspid aortic valve / Circulation 106:900~904
Prakash SK / 2014 / A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium) / J Am Coll Cardiol 64:832~839
Verma S / 2014 / Aortic dilatation in patients with bicuspid aortic valve / N Engl J Med 370:1920~1929
Roger VL / 2011 / Heart disease and stroke statistics--2011 update: a report from the American Heart Association / Circulation 123:e18~e209
Fedak PW / 2002 / Clinical and pathophysiological implications of a bicuspid aortic valve / Circulation 106:900~904
Prakash SK / 2014 / A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium) / J Am Coll Cardiol 64:832~839
Verma S / 2014 / Aortic dilatation in patients with bicuspid aortic valve / N Engl J Med 370:1920~1929
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