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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 102 - 106 (5page)
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초록· 키워드
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BackgroundBloodstream infections (BSI) remain a frequent complication during the pre-engraftment period after hematopoietic stem cell transplantation (HSCT), resulting in high mortality rates. This study evaluated risk factors for mortality in hematopoietic stem cell transplant recipients with BSI in the pre-engraftment period.MethodsThis prospective case control study was performed at the Center of Hematology and Bone Marrow Transplantation in Minsk, Republic of Belarus. Data relating to patient age and gender, date and type of transplantation, conditioning chemotherapy regimen, micro-organisms isolated from blood, and antibacterial therapy were prospectively collected from all hematopoietic stem cell recipients with microbiologically proven cases of BSI in the pre-engraftment period. The primary outcome was all-cause 30-day mortality after onset of febrile neutropenia. ResultsA total of 135 adult patients with microbiologically proven BSI after HSCT were studied, with 65.2% of cases caused by gram-negative microorganisms and 21.5% by non-fer-menting bacteria. Inadequate empiric antibacterial therapy and isolation of carbape-nem-resistant non-fermenting gram-negative bacteria (Acinetobacter baumannii and Pseudomonas aeruginosa) were independently associated with increased all-cause 30-day mortality in these patients. ConclusionThe risk factors for mortality in adult patients with BSI in the pre-engraftment period after HSCT were inadequacy of empirical antibacterial therapy and isolation of carbapenem-re-sistant A. baumannii or P. aeruginosa.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Poutsiaka DD / 2007 / Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality / Bone Marrow Transplant 40:63~70
Mikulska M / 2009 / Blood stream infections in allogeneic hematopoietic stem cell transplant recipients:reemergence of Gram-negative rods and increasing antibiotic resistance / Biol Blood Marrow Transplant 15:47~53
Marena C / 2001 / Incidence of, and risk factors for, nosocomial infections among hematopoietic stem cell transplantation recipients, with impact on procedure-related mortality / Infect Control Hosp Epidemiol 22:510~517
Mossad SB / 1996 / Early infectious complications in autologous bone marrow transplantation: a review of 219 patients / Bone Marrow Transplant 18:265~271
Vydra J / 2012 / Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation / Clin Infect Dis 55:764~770
Mikulska M / 2009 / Blood stream infections in allogeneic hematopoietic stem cell transplant recipients:reemergence of Gram-negative rods and increasing antibiotic resistance / Biol Blood Marrow Transplant 15:47~53
Marena C / 2001 / Incidence of, and risk factors for, nosocomial infections among hematopoietic stem cell transplantation recipients, with impact on procedure-related mortality / Infect Control Hosp Epidemiol 22:510~517
Mossad SB / 1996 / Early infectious complications in autologous bone marrow transplantation: a review of 219 patients / Bone Marrow Transplant 18:265~271
Vydra J / 2012 / Enterococcal bacteremia is associated with increased risk of mortality in recipients of allogeneic hematopoietic stem cell transplantation / Clin Infect Dis 55:764~770
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