지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 171 - 174 (4page)
이용수
초록· 키워드
오류제보하기
BackgroundUnfractionated heparin (UFH) has unstable pharmacokinetics and requires close monitoring. The activated partial thromboplastin time (aPTT) test has been used to mon-itor UFH therapy for decades in Korea, but its results can be affected by numerous variables. We established an aPTT heparin therapeutic range (HTR) corresponding to ther-apeutic anti-Xa levels for continuous intravenous UFH administration, and used appro-priate monitoring to determine if an adequate dose of UFH was applied.MethodsA total of 134 ex vivo samples were obtained from 71 patients with a variety of thromboembolisms. All patients received intravenous UFH therapy and were enrolled from June to September 2015 at Gyeongsang National University Hospital. All laboratory protocols were in accordance with the Clinical and Laboratory Standards Institute guide-lines and the College of American Pathologist requirements for aPTT HTR. ResultsAn aPTT range of 87.1 sec to 128.7 sec corresponded to anti-Xa levels of 0.3 IU/mL to 0.7 IU/mL for HTR under our laboratory conditions. Based on their anti-Xa levels, blood specimen distribution were as follows: less than 0.3 IU/mL, 65.7%; 0.3‒0.7 IU/mL (ther-apeutic range), 33.6%; and more than 0.7 IU/mL, 0.7%. No evidence of recurring throm-boembolism was observed. ConclusionUsing the conventional aPTT target range may lead to inappropriate dosing of UFH. Transitioning from the aPTT test to the anti-Xa assay is required to avoid the laborious validation of the aPTT HTR test, even though the anti-Xa assay is more expensive.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Guervil DJ / 2011 / Activated partial thromboplastin time versus antifactor Xa heparin assay in monitoring unfractionated heparin by continuous intravenous infusion / Ann Pharmacother 45:861~868
Baglin T / 2006 / Guidelines on the use and monitoring of heparin / Br J Haematol 133:19~34
Warkentin TE / 2002 / Reversing anticoagulants both old and new / Can J Anaesth 49:S11~S25
McGlasson DL / 2005 / Effects of pre-analytical variables on the anti-activated factor X chromogenic assay when monitoring unfractionated heparin and low molecular weight heparin anticoagulation / Blood Coagul Fibrinolysis 16:173~176
Vandiver JW / 2012 / Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin / Pharmacotherapy 32:546~558
Baglin T / 2006 / Guidelines on the use and monitoring of heparin / Br J Haematol 133:19~34
Warkentin TE / 2002 / Reversing anticoagulants both old and new / Can J Anaesth 49:S11~S25
McGlasson DL / 2005 / Effects of pre-analytical variables on the anti-activated factor X chromogenic assay when monitoring unfractionated heparin and low molecular weight heparin anticoagulation / Blood Coagul Fibrinolysis 16:173~176
Vandiver JW / 2012 / Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin / Pharmacotherapy 32:546~558
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