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학술저널
저자정보
Tine Gregersen (Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark) Christina Brock (Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark) Anne-Mette Haase (Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark) Søren Laurberg (Department of Surgery P Aarhus University Hospital Aarhus Denmark) Asbjørn M Drewes (Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark) Henning Grønbæk (Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark) Klaus Krogh (Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.22 No.2
발행연도
2016.1
수록면
264 - 271 (8page)

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Background/AimsIn patients with neuroendocrine tumors, excessive production of serotonin and other amines may cause the carcinoid syndrome,which is mainly characterized by diarrhea and flushing. Little is known about the pathophysiology of carcinoid diarrhea. In severalother groups of patients, diarrhea may be associated with rectal hypersensitivity and increased rectal tone. Therefore, the aim of thepresent study was to compare rectal sensitivity and compliance in patients with carcinoid diarrhea and in healthy subjects. MethodsTwelve patients (6 males, aged 54-78 years, median 65 years), with carcinoid diarrhea and 19 healthy subjects (7 males, aged 50-78years, median 61 years) were included. Rectal mechanical and heat stimulation was used for assessment of rectal mechano-sensoryproperties. ResultsOverall, 5.3% higher temperatures were needed to elicit sensory responses in patients with carcinoid diarrhea than in healthy subjects(P = 0.015). Posthoc analyses revealed that the sensory threshold to heat was 48.1 ± 3.1oC in patients vs 44.7 ± 4.7oC in healthysubjects (P = 0.041). In contrast, patients and healthy subjects showed no overall differences in rectal sensory response to mechanicaldistension (P = 0.731) or rectal compliance (P = 0.990). ConclusionsPatients with carcinoid diarrhea have higher sensory thresholds to heat stimulation in comparison to healthy subjects, but normalrectal sensation to mechanical distension and normal compliance. Therefore, treatment of carcinoid diarrhea should aim at prolonginggastrointestinal transit and decreasing secretion, rather than modifying rectal mechano-sensory function.

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