Effects of the Administration of Probiotics on Fecal Microbiota Diversity and Composition in Healthy Individuals

Choong-Kyun Noh; Bong Sun Kim; Gana Hong; Jae Youn Cheong; Kwang Jae Lee

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자료유형: 학술저널

저자정보: Choong-Kyun Noh (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea) Bong Sun Kim (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea) Gana Hong (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea) Jae Youn Cheong (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea) Kwang Jae Lee (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea)

저널정보: 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.3

발행연도: 2018.1

수록면: 452 - 459 (8page)

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Background/Aims Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. Methods Twelve healthy volunteers with age range of 30–42 years provided baseline fecal samples. Subsequently, they took commercially available probiotic capsules (a mixture for Bifidobacterium, Lactobacillus, and Enterococcus) for 4 weeks. Fecal samples were collected at 4 weeks of administration and 2 weeks after the stop of administration. Fecal microbiota was analyzed via 16S ribosomal RNA gene sequencing. Results The mean Shannon index was not significantly altered by the 4-week administration of probiotics (4.365 vs 4.556, P > 0.05). The proportion of Bacteroidetes, Actinobacteria, Firmicutes, and Proteobacteria was not significantly changed by the 4-week administration of probiotics. At the genus level, the proportions of Lactobacillus (2.138% vs 2.773%, P = 0.028) and Enterococcus (0.022% vs 2.758%, P = 0.004) significantly increased 4 weeks after the administration of probiotics, but reduced 2 weeks after the stop of administration (2.773% vs 3.292%, P = 0.064 and 2.758% vs 0.001%, P = 0.001). Conclusions The diversity of fecal microbiota is not significantly affected by 4 weeks of probiotics administration. The proportion of fecal microbiota at the genus level is significantly altered by the administration of probiotics. However, this effect does not seem to last long, probably because of homeostasis or dietary influence.

참고문헌 (30)

참고문헌 신청

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