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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Cervical cancer is a major public health problem in Morocco. The cervical cancer has a long precancerous period that provides an opportunity for the screening and treatment. Improving screening tests is a priority goal for the early diagnosis of cervical cancer. This study was conducted to evaluate the combination of p16INK4a protein expression, human papillomavirus (HPV) typing, and histopathology for the identification of cervical lesions with high risk to progress to cervical cancer among Moroccan women. A total of 96 cervical biopsies were included in this study. Signal amplification in situ hybridization with biotinylated probes was used to detect HPV. Immunohistochemistry was used to evaluate the expression of p16INK4a protein. HPV DNA was detected in 74.0% of the biopsies (71/96). Of the seventy-one positive HPV cases, we detected 67.6% (48/71) of high risk (HR)-HPV (HPV 16 and 18), 24% of low risk-HPV (HPV 6 and 11), 1.4% intermediate risk-HPV (HPV 31, 33, and 35), and 7% coinfections (HPV 6/11 and 16/18). Overexpression of p16INK4a protein was observed in 72.9% (70/96) of the biopsies. In addition, p16INK4a protein detection was closely correlated with recovery of HR HPV. Our result showed that p16INK4a expression level is correlated with HR-HPV status. (J Cancer Prev 2016;21:121-125)
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참고문헌 (30)
참고문헌 신청
Ferlay J / GLOBOCAN 2012 v1.0. Estimated Cancer Incidence and Mortality Worldwide in 2012; IARC CancerBase No. 11
Attaleb M / 2009 / Status of p16(INK4a) and E-cadherin gene promoter methylation in Moroccan patients with cervical carcinoma / Oncol Res 18:185~192
Alhamany Z / 2010 / Prevalence of human papillomavirus genotype among Moroccan women during a local screening program / J Infect Dev Ctries 4:732~739
Phelps WC / 1988 / The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A / Cell 53:539~547
Dyson N / 1989 / The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product / Science 243:934~937
Attaleb M / 2009 / Status of p16(INK4a) and E-cadherin gene promoter methylation in Moroccan patients with cervical carcinoma / Oncol Res 18:185~192
Alhamany Z / 2010 / Prevalence of human papillomavirus genotype among Moroccan women during a local screening program / J Infect Dev Ctries 4:732~739
Phelps WC / 1988 / The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A / Cell 53:539~547
Dyson N / 1989 / The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product / Science 243:934~937
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