지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 235 - 241 (7page)
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초록· 키워드
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ObjectiveTo identify the specific human papillomavirus (HPV) genotypes from HPV-other type on an HPV DNA chip test bysequencing. MethodsAmong 13,600 women undergoing a routine gynecology examination including Pap smear and/or HPV test by DNAchip test in the healthcare system at Gangnam Center from July 2012 to February 2013, we prospectively collectedand performed sequencing for a total of 351 consecutive cervicovaginal samples consisting of 180 samples that testedpositive for HPV-other type and 171 samples that tested positive for either high-risk HPV or low-risk HPV. ResultsOf a total of 351 samples, individual HPV genotypes were successfully sequenced in 215 cases: 119 HPV-other type, 82HPV-high-risk, and 14 HPV-low-risk. Based on the sequencing for 119 HPV-other type samples, 91.6% were detectedas HPV types that were not included on the DNA chip; however, 7.6% (9/119) were proven to be high-risk HPV types:HPV 18 (n=4), HPV 33 (n=3), HPV 35 (n=1), and HPV 59 (n=1). For correlation analysis of all high-risk and HPV 16/18,the correlation rate was 76.2% and 86.6% with kappa-value of 0.38 and 0.69, respectively. ConclusionHPV-other type on DNA chip test may still have possibility of high-risk HPV, i.e., HPV 18 and thus the significance ofHPV-other type in detecting cervical disease remains to be investigated.
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참고문헌 (25)
참고문헌 신청
Clifford GM / 2005 / Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer / Cancer Epidemiol Biomarkers Prev 14:1157~1164
Naucler P / 2007 / HPV type-specific risks of high-grade CIN during 4 years of follow-up: a population-based prospective study / Br J Cancer 97:129~132
Khan MJ / 2005 / The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of typespecific HPV testing in clinical practice / J Natl Cancer Inst 97:1072~1079
Bosch FX / 2003 / Chapter 1: human papillomavirus and cervical cancer--burden and assessment of causality / J Natl Cancer Inst Monogr :3~13
An HJ / 2003 / Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method / Cancer 97:1672~1680
Naucler P / 2007 / HPV type-specific risks of high-grade CIN during 4 years of follow-up: a population-based prospective study / Br J Cancer 97:129~132
Khan MJ / 2005 / The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of typespecific HPV testing in clinical practice / J Natl Cancer Inst 97:1072~1079
Bosch FX / 2003 / Chapter 1: human papillomavirus and cervical cancer--burden and assessment of causality / J Natl Cancer Inst Monogr :3~13
An HJ / 2003 / Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method / Cancer 97:1672~1680
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