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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 7 (7page)
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To identify disrupted pathways associated with neonatal sepsis, we performed a research based on the combination of protein-protein interactions (PPIs) and pathway data. Firstly, a total of 23,292 genes, 787,896 PPIs and 1,675 human pathways were obtained, respectively. Then, under the threshold value of false discovery rate (FDR)<0.05 and a delta cut-off value >4.36, a total of 986 differentially expressed genes (DEGs) were identified. In the following, by degree centrality for the objective PPI network, 20 hub genes were obtained. Finally, pathway enrichment analysis and randomization tests indicated that pathways of gene expression, immune system and innate immune system were with remarkable significance in neonatal sepsis. Therefore, in the present study, we presented a novel pathway method, and we successfully identified several pathways in neonatal sepsis, which might be underlying indicators in the detection and treatment of neonatal sepsis.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Samsygina, G.A. / 2004 / Sepsis in the newborn / Arkh. Patol (Suppl):1~48
Liu, L. / 2012 / Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 200 / Lancet 379:2151~2161
Vergnano, S. / 2005 / Neonatal sepsis: an international perspective / Arch. Dis. Child. Fetal Neonatal Ed :F220~F224
Lupu, F / 2014 / Crosstalk between the coagulation and complement systems in sepsis / Thrombosis Research 133:S28~S31
Streimish, I. / 2014 / Neutrophil CD64 with hematologic criteria for diagnosis of neonatal sepsis / Am. J. Perinatol 31:21~30
Liu, L. / 2012 / Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 200 / Lancet 379:2151~2161
Vergnano, S. / 2005 / Neonatal sepsis: an international perspective / Arch. Dis. Child. Fetal Neonatal Ed :F220~F224
Lupu, F / 2014 / Crosstalk between the coagulation and complement systems in sepsis / Thrombosis Research 133:S28~S31
Streimish, I. / 2014 / Neutrophil CD64 with hematologic criteria for diagnosis of neonatal sepsis / Am. J. Perinatol 31:21~30
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