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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 244 - 248 (5page)
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Approximately one-third of patients with Crohn’s disease do not respond to conventional treatments, and some experiencesignificant adverse effects, such as serious infections and lymphoma, and many patients require surgery due to complications. Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are acommon feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immunesystem, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation,aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternativetherapeutic option for IBD. Herein, we present a patient with Crohn’s colitis in whom biologic therapy failed previously, butclinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.
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참고문헌 (15)
참고문헌 신청
이강문 / 2014 / Crohn’s disease in Korea: past, present, and future / The Korean Journal of Internal Medicine 29(5):558~570
Manichanh C / 2012 / The gut microbiota in IBD / Nat Rev Gastroenterol Hepatol 9:599~608
김남희 / 2014 / Long-Term Clinical Outcomes of Korean Patient With Crohn’s Disease Following Early Use of Infliximab / Intestinal research 12(4):281~286
Wang ZK / 2014 / Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease / World J Gastroenterol 20:14805~14820
Colman RJ / 2014 / Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis / J Crohns Colitis 8:1569~1581
Manichanh C / 2012 / The gut microbiota in IBD / Nat Rev Gastroenterol Hepatol 9:599~608
김남희 / 2014 / Long-Term Clinical Outcomes of Korean Patient With Crohn’s Disease Following Early Use of Infliximab / Intestinal research 12(4):281~286
Wang ZK / 2014 / Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease / World J Gastroenterol 20:14805~14820
Colman RJ / 2014 / Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis / J Crohns Colitis 8:1569~1581
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