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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 26 - 42 (17page)
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Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 mainclinical phenomena: Crohn’s disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD, including CD and UC, involvesthe presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes,and gene variants. Although many investigations have tried to identify novel pathogenic factors associated with IBD that are related to environmental, genetic, microbial, and immune response factors, a full understanding of IBD pathogenesis is unclear. Thus, IBD treatment is far from optimal, and patient outcomes can be unsatisfactory. As result of massive studying on IBD, Thelper 17 (Th17) cells and innate lymphoid cells (ILCs) are investigated on their effects on IBD. A recent study of the plasticityof Th17 cells focused primarily on colitis. ILCs also emerging as novel cell family, which play a role in the pathogenesis of IBD. IBD immunopathogenesis is key to understanding the causes of IBD and can lead to the development of IBD therapies. Theaim of this review is to explain the pathogenesis of IBD, with a focus on immunological factors and therapies.
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참고문헌 (184)
참고문헌 신청
Bernstein CN / 2009 / Inflammatory bowel disease: a global perspective. Global guidelines / World Gatroenterology Organization
Baumgart DC / 2007 / Inflammatory bowel disease: clinical aspects and established and evolving therapies / Lancet 369:1641~1657
Leppkes M / 2009 / RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F / Gastroenterology 136:257~267
Lee SY / 2015 / Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/Treg balance / PLoS One 10:e0135858
Dinarello CA / 2009 / Interleukin-1beta and the autoinflammatory diseases / N Engl J Med 360:2467~2470
Baumgart DC / 2007 / Inflammatory bowel disease: clinical aspects and established and evolving therapies / Lancet 369:1641~1657
Leppkes M / 2009 / RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F / Gastroenterology 136:257~267
Lee SY / 2015 / Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/Treg balance / PLoS One 10:e0135858
Dinarello CA / 2009 / Interleukin-1beta and the autoinflammatory diseases / N Engl J Med 360:2467~2470
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