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자료유형
학술저널
저자정보
이승훈 (Harvard Medical School) Jeong eun Kwon (The Catholic University of Korea) 조미라 (가톨릭대학교)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.16 No.1
발행연도
2018.1
수록면
26 - 42 (17page)

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Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 mainclinical phenomena: Crohn’s disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD, including CD and UC, involvesthe presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes,and gene variants. Although many investigations have tried to identify novel pathogenic factors associated with IBD that are related to environmental, genetic, microbial, and immune response factors, a full understanding of IBD pathogenesis is unclear. Thus, IBD treatment is far from optimal, and patient outcomes can be unsatisfactory. As result of massive studying on IBD, Thelper 17 (Th17) cells and innate lymphoid cells (ILCs) are investigated on their effects on IBD. A recent study of the plasticityof Th17 cells focused primarily on colitis. ILCs also emerging as novel cell family, which play a role in the pathogenesis of IBD. IBD immunopathogenesis is key to understanding the causes of IBD and can lead to the development of IBD therapies. Theaim of this review is to explain the pathogenesis of IBD, with a focus on immunological factors and therapies.

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