지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 25 - 40 (16page)
이용수
초록· 키워드
오류제보하기
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an unknown etiology. IBD is
composed of two different disease entities: Crohn’s disease (CD) and ulcerative colitis (UC). IBD has been thought to
be idiopathic but has two main attributable causes that include genetic and environmental factors. The gastrointestinal
tract in which this disease occurs is central to the immune system, and the innate and the adaptive immune systems
are balanced in complex interactions with intestinal microbes under homeostatic conditions. However, in IBD, this
homeostasis is disrupted and uncontrolled intestinal inflammation is perpetuated. Recently, the pathogenesis of IBD
has become better understood owing to advances in genetic and immunologic technology. Moreover, new therapeutic
strategies are now being implemented that accurately target the pathogenesis of IBD. Beyond conventional immunesuppressive
therapy, the development of biological agents that target specific disease mechanisms has resulted in
more frequent and deeper remission in IBD patients, with mucosal healing as a treatment goal of therapy. Future
novel biologics should overcome the limitations of current therapies and ensure that individual patients can be treated
with optimal drugs that are safe and precisely target IBD.
목차
INTRODUCTION
The intestinal epithelium and microbiot a
Innate and adaptive immunity in IBD treatment
Conclusion
REFERENCES
참고문헌 (142)
참고문헌 신청
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Maloy, K. J., and F. Powrie. 2011. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474: 298-306.
Cader, M. Z., and A. Kaser. 2013. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 62: 1653-1664.
Podolsky, D. K. 1991. Inflammatory bowel disease. N. Engl. J. Med. 325: 928-937.
Abraham, C., and J. H. Cho. 2009. Inflammatory bowel disease. N. Engl. J. Med. 361: 2066-2078.
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UCI(KEPA) : I410-ECN-0101-2017-517-002233584