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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 297 - 303 (7page)
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A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Singer AJ / 1999 / Cutaneous wound healing / N Engl J Med 341:738~746
Nie C / 2011 / Locally administered adiposederived stem cells accelerate wound healing through differentiation and vasculogenesis / Cell Transplant 20:205~216
Reddy JS / 2002 / Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats / J Ethnopharmacol 79:249~251
Panopoulos AD / 2008 / Granulocyte colony-stimulating factor : molecular mechanisms of action during steady state and ‘emergency’hematopoiesis / Cytokine 42:277~288
Minatoguchi S / 2004 / Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment / Circulation 109:2572~2580
Nie C / 2011 / Locally administered adiposederived stem cells accelerate wound healing through differentiation and vasculogenesis / Cell Transplant 20:205~216
Reddy JS / 2002 / Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats / J Ethnopharmacol 79:249~251
Panopoulos AD / 2008 / Granulocyte colony-stimulating factor : molecular mechanisms of action during steady state and ‘emergency’hematopoiesis / Cytokine 42:277~288
Minatoguchi S / 2004 / Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment / Circulation 109:2572~2580
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