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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 59 - 68 (10page)
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BACKGROUND: This study was conducted to investigate the effect of granulocyte–macrophage colony-stimulating factor (GM-CSF) on the mobilization of mesenchymal stem cells (MSCs) from the bone marrow (BM) into the peripheral blood (PB) in rats. METHODS: GM-CSF was administered subcutaneously to rats at 50 lg/kg body weight for 5 consecutive days. The BM and PB of rats were collected at 1, 3, and 5 days during the administration for analysis. RESULTS: Upon GM-CSF administration, the number of mononuclear cells increased rapidly at day 1 both in the BM and PB. This number decreased gradually over time in the BM to below the initial amount by day 5, but was maintained at a high level in the PB until day 5. The colony-forming unit–fibroblasts were increased in the PB by 10.3-fold at day 5 of GM-CSF administration, but decreased in the BM. Compared to GM-CSF, granulocyte-colony stimulating factor (G-CSF) stimulated lower levels of MSC mobilization from the BM to the PB. Immunohistochemical analysis revealed that GMCSF induced a hypoxic and proteolytic microenvironment and increased C-X-C chemokine receptor type 4 (CXCR4) expression in the BM. GM-CSF added to BM MSCs in vitro dose-dependently increased CXCR4 expression and cell migration. G-CSF and stromal cell derived factor-1 (SDF-1) showed similar results in these in vitro assays. Know-down of CXCR4 expression with siRNA significantly abolished GM-CSF- and G-CSF-induced MSC migration in vitro, indicating the involvement of the SDF-1–CXCR4 interaction in the mechanism. CONCLUSION: These results suggest that GM-CSF is a useful tool for mobilizing BM MSCs into the PB.
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참고문헌 (45)
참고문헌 신청
Yagi H / 2010 / Mesenchymal stem cells : mechanisms of immunomodulation and homing / Cell Transplant 19:667~679
de Sousa EB / 2014 / Synovial fluid and synovial membrane mesenchymal stem cells : lastest discoveries and therapeutic perspectives / Stem Cell Res Ther 5:112
Beatriz A. Rodas-Junco / 2017 / Dental Pulp Stem Cells: Current Advances in Isolation, Expansion and Preservation / 조직공학과 재생의학 14(4):333~347
Mahsa Sani / 2017 / Diff erentiation Potential of Breast Milk-Derived Mesenchymal Stem Cells into Hepatocyte-Like Cells / 조직공학과 재생의학 14(5):587~593
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284:143~147
de Sousa EB / 2014 / Synovial fluid and synovial membrane mesenchymal stem cells : lastest discoveries and therapeutic perspectives / Stem Cell Res Ther 5:112
Beatriz A. Rodas-Junco / 2017 / Dental Pulp Stem Cells: Current Advances in Isolation, Expansion and Preservation / 조직공학과 재생의학 14(4):333~347
Mahsa Sani / 2017 / Diff erentiation Potential of Breast Milk-Derived Mesenchymal Stem Cells into Hepatocyte-Like Cells / 조직공학과 재생의학 14(5):587~593
Pittenger MF / 1999 / Multilineage potential of adult human mesenchymal stem cells / Science 284:143~147
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