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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 243 - 251 (9page)
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초록· 키워드
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Several clinical conditions may limit the success of bone regeneration and/or implant osseointegration. For this reason, many compounds have been tested for their ability to stimulate this biological process. Synthetic hydroxyapatite (HA), mimicking natural bone hydroxyapatite, and extra-cellular matrix proteins, such as type I collagen, are potential candidates. However, the synthetic origin of HA and the denaturing conditions required for extracting collagen from skin and derma are sources of potential drawbacks. This study examines the in vitro effects of a natural bone derivative (NBD) extracted from equine bone and containing both natural, non-synthetic bone hydroxyapatite and native, non-denatured, type I bone collagen as a possible active compound for stimulating bone regeneration and implant osseointegration. The activity of NBD was tested on bone marrow stromal cells (BMSCs), evaluating their growth/viability by the methylthiazol tetrazolium (MTT) assay and their migration potential by a scratch assay. Moreover, expression of the hyaluronic acid receptor (CD44) and the C-X-C chemokine receptor type 4 (CXCR4, CD184) on the surface of BMSCs was assessed by flow cytometry, and the release of Transforming Growth Factor (TGF)-b, Interleukin (IL)-1a and IL-6 was quantified using an enzyme-linked immunosorbent assay (ELISA). The effect of NBD-coated implants on human osteoblasts was tested by measuring alkaline phosphatase (ALP) activity with the p-nitrophenyl phosphate (pNPP) degradation test. NBD stimulated BMSC growth/viability, migration, CD184 surface expression and the release of TGF-b1. NBD-coated implants increased ALP activity of human osteoblasts. These results indicate that NBD may be an adjuvant to accelerate both bone regeneration and osseointegration.
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참고문헌 (43)
참고문헌 신청
Belser UC / 2000 / Prosthetic management of the partially dentate patient with fixed implant restorations / Clin Oral Implants Res 11(Suppl 1):126~415
장희원 / 2011 / A retrospective study on related factors affecting the survival rate of dental implants / The Journal of Advanced of Prosthodontics 3(4):204~215
Esposito M / 2009 / The efficacy of horizontal and vertical bone augmentation procedures for dental implants—a Cochrane systematic review / Eur J Oral Implantol 2:167~184
Mavrogenis AF / 2009 / Biology of implant osseointegration / J Musculoskelet Neuronal Interact 9:61~71
Ka¨mmerer PW / 2011 / Immobilisation of linear and cyclic RGD-peptides on titanium surfaces and their impact on endothelial cell adhesion and proliferation / Eur Cell Mater 21:364~372
장희원 / 2011 / A retrospective study on related factors affecting the survival rate of dental implants / The Journal of Advanced of Prosthodontics 3(4):204~215
Esposito M / 2009 / The efficacy of horizontal and vertical bone augmentation procedures for dental implants—a Cochrane systematic review / Eur J Oral Implantol 2:167~184
Mavrogenis AF / 2009 / Biology of implant osseointegration / J Musculoskelet Neuronal Interact 9:61~71
Ka¨mmerer PW / 2011 / Immobilisation of linear and cyclic RGD-peptides on titanium surfaces and their impact on endothelial cell adhesion and proliferation / Eur Cell Mater 21:364~372
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