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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 587 - 593 (7page)
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Human breast milk stem cells (hBSCs) contain a population of cells with the ability to differentiate into various cell lineages for cell therapy applications. The current study examined the differentiation potential of hBSCs into hepatocytes- like cells. The cells were isolated from the breast milk and were treated with hepatogenic medium containing hepatocyte growth factor, insulin-like growth factor and dexamethasone for 7 days subsequently; Oncostatin M was added to the culture media. RT-PCR and immunocytochemistry were performed to detect the hepatogenic markers. The glycogen storage and the ability of the cells to absorb and release indocynanin green were also tested. The data showed that most of the differentiated cells formed cell aggregates after the 30th day, with more cells accumulated to form spheroids. RT-PCR revealed the expression of the hepatic nuclear factor, albumin, cytokeratin 18 and 19, cytochrome P2B6, glucose-6- phospahtase and claudin. The functional assays also showed glycogen storage and omission of indicynine green. Our study demonstrated hBSCs are novel population that can differentiate into hepatocyte-like cells.
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참고문헌 (24)
참고문헌 신청
Hassiotou F / 2012 / Breastmilk is a novel source of stem cells with multilineage differentiation potential / Stem Cells 30:2164~2174
Patki S / 2010 / Human breast milk is a rich source of multipotent mesenchymal stem cells / Hum Cell 23:35~40
Sani M / 2015 / Origins of the breast milk-derived cells; an endeavor to find the cell sources / Cell Biol Int 39:611~618
Hosseini SM / 2014 / Differentiation of human breast-milk stem cells to neural stem cells and neurons / Neurol Res Int 2014:1~8
Ayatollahi M / 2012 / Human bone marrow-derived mesenchymal stem cell : a source for cell-based therapy / Int J Organ Transpl Med 3:32~41
Patki S / 2010 / Human breast milk is a rich source of multipotent mesenchymal stem cells / Hum Cell 23:35~40
Sani M / 2015 / Origins of the breast milk-derived cells; an endeavor to find the cell sources / Cell Biol Int 39:611~618
Hosseini SM / 2014 / Differentiation of human breast-milk stem cells to neural stem cells and neurons / Neurol Res Int 2014:1~8
Ayatollahi M / 2012 / Human bone marrow-derived mesenchymal stem cell : a source for cell-based therapy / Int J Organ Transpl Med 3:32~41
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