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논문 기본 정보

자료유형
학술저널
저자정보
Shariq Najeeb (Al-Farabi Colleges) Zohaib Khurshid (The University of Western Ontario) Muhammad Atif Saleem Agwan (Qassim University) Shazia Akhbar Ansari (Dow University of Health Sciences) Muhammad Sohail Zafar (Taibah University College of Dentistry) Jukka Pekka Matinlinna (The University of Hong Kong)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제14권 제6호
발행연도
2017.1
수록면
735 - 742 (8page)

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Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its use has been advocated for regenerative periodontics and wound healing. The randomized control trials have assessed the regenerative efficacy of the PRF for restoring intrabony periodontal defects.The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: ‘platelet-rich fibrin’, ‘intrabony’, ‘periodontal’, ‘bone defect’ and ‘guided tissue regeneration’.Asecondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being included. Inmajority of studies, PRF resulted in better clinical/radiographic outcomes than open flap debridement and augmented therapeutic effects of bone grafts. The combination of bovine bone substitutes and PRF resulted in better performance compared to alone. Similarly better outcomes were observed while using PRF in combination with nanohydroxyapatite, metformin and demineralized freeze-dried bone allograft. It can be concluded that PRF produces better outcomes than open flap debridement alone and augments the regenerative effects of bone substitutes.

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