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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.24 No.2
- 발행연도
- 2017.1
- 수록면
- 148 - 152 (5page)
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초록· 키워드
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Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities of the leukemic blast. Concurrent MYC and IGH/BCL2 translocations have recently been reported as a “double hit” in adult patients, but non-immunoglobulin (non-IG)/MYC translocation has rarely been reported. In this paper, we report a case of pediatric precursor B-cell ALL associated with translocations (14;18)(q32;q21) and (8;9)(q24;p13). The patient was a previously healthy 13-year-old boy. Complete remission was not achieved after first-line four-drug induction chemotherapy; thus, intensive salvage regimen, including high-dose cytarabine and L-asparaginase, were administered, which resulted in morphologic remission. However, his disease relapsed during the second cycle of salvage regimen, and he died of sepsis-induced multiorgan failure.
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참고문헌 (15)
참고문헌 신청
Wang S / 2016 / 2016 Revision to the WHO classification of acute lymphoblastic leukemia / J Transl Int Med 4:147~149
Mrózek K / 2009 / Cytogenetics and molecular genetics of acute lymphoblastic leukemia / Hematol Oncol Clin North Am 23:991~1010
Haberl S / 2016 / MYC rearranged B-cell neoplasms: Impact of genetics on classification / Cancer Genet 209:431~439
Navid F / 1999 / Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3morphology associated with a B-precursor immunophenotype:the Pediatric Oncology Group experience / Leukemia 13:135~141
Chapiro E / 2013 / Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature / Cancer Genet 206:162~173
Mrózek K / 2009 / Cytogenetics and molecular genetics of acute lymphoblastic leukemia / Hematol Oncol Clin North Am 23:991~1010
Haberl S / 2016 / MYC rearranged B-cell neoplasms: Impact of genetics on classification / Cancer Genet 209:431~439
Navid F / 1999 / Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3morphology associated with a B-precursor immunophenotype:the Pediatric Oncology Group experience / Leukemia 13:135~141
Chapiro E / 2013 / Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature / Cancer Genet 206:162~173
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