Comparison of Reconstructed Human Skin Models with Human and Pig Skin in in-vitro Percutaneous Absorption

Ju-Hee Han; C-Yoon Kim; Chae-Hyung Lim; Yi-Rang Na; Tae-Hyoun Kim; Hyun Jung; Seung-Hyeok Seok; Cho-Rok Jung; Jae-Hak Park

Comparison of Reconstructed Human Skin Models with Human and Pig Skin in in-vitro Percutaneous Absorption

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인공피부모델과 사람, 돼지 피부의 피부흡수시험 비교 검증 연구

Type: Academic journal

Author: Ju-Hee Han (서울대학교 수의과대학) C-Yoon Kim (서울대학교 수의과대학) Chae-Hyung Lim (식약처 서울지방식약청) Yi-Rang Na (서울대학교 수의과대학) Tae-Hyoun Kim (서울대학교 수의과대학) Hyun Jung (서울대학교 수의과대학) Seung-Hyeok Seok (서울대학교 의과대학) Cho-Rok Jung (한국생명공학연구원 줄기세포연구센터) Jae-Hak Park (서울대학교 수의과대학)

Journal: 한국동물실험대체법학회 한국동물실험대체법학회 한국동물실험대체법학회 제11권 제1호

Published: 2017.1

Pages: 1 - 8 (8page)

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Comparison of Reconstructed Human Skin Models with Human and Pig Skin in in-vitro Percutaneous Absorption

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This study was carried out in accordance with OECD guidelines on skin absorption test for the comparison of reconstructed human skin models, EFT-306™ and KeraSkinFT™ with human skin and pig skin. Three OECD standard compounds were used for penetration and absorption: Caffeine, benzoic acid and testosterone, all of which differ vastly in their lipophilicity. Reconstructed human skins were more permeable to low lipophilic compounds such as caffeine than human and pig skin. Differences became most obvious with KeraSkinFT™ showing a relatively weak penetration barrier on caffeine. EFT-306™ and KeraSkinFT™ both showed similar penetration patterns in the case of lipophilic compounds, benzoic acid and testosterone compared with human and pig skins. High correlation was observed on the penetration flux between the reconstructed human skin models and human and pig skin, even though different penetration rates existed. The reconstructed human skin models can be regarded as generally useful on lipophilic compounds for in-vitro penetration studies.

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References (23)

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안준호 / 2010 / Assessment of the Dermal and Ocular Irritation Potential of Lomefloxacin by Using In Vitro Methods / 한국독성학회지 26(1):9~14

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최종혜 / 2014 / Skin Corrosion and Irritation Test of Sunscreen Nanoparticles using Reconstructed 3D Human Skin Model / 환경독성보건학회지 29:1~10

Coquette A / 2003 / Analysis of interleukin-1alpha (IL-1alpha) and interleukin-8 (IL-8) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization / Toxicol In Vitro 17:311~321

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