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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 57 - 57 (1page)
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Metabolomics is the technology of studying, profiling, and fingerprinting metabolites in various physiologic states. This approach has recently demonstrated enormous potentials in many fields such as genotype discrimination, toxicological mechanism, disease processes, and drug discovery. Metabonomic approaches have been used to generate comprehensive biochemical profiles of low molecular weight endogenous metabolites for biofluides and tissue. This metabolic profile is perturbed in a characteristic fashion in disease, toxic process and drug efficacy, and this shift in position can be readily visualized and modeled using chemometric techniques. The metabolic profile of biofluids shows changes of their composition in response to toxic or disease-induced stress due to the system"s attempt to maintain homeostasis. These methods constitute a metabolomic approach to study the quantitative metabolic consequences of patho-physiological insult. Understanding the biochemical reason for such a shift in metabolic space leads to the identification of biomarkers of disease or drug effic^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10819350');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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