Survival Improvement in Korean Breast Cancer Patients Due to Increases in Early-Stage Cancers and Hormone Receptor Positive/HER2 Negative Subtypes: A Nationwide Registry-Based Study

Jee Man You; Yun Gyoung Kim; 문형곤                                         /Hyeong-Gon Moon; 남석진; 이정언; 임우성; 이미리; 노동영                                         /Dong-Young Noh; 한원식

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자료유형: 학술저널

저자정보: Jee Man You Yun Gyoung Kim 문형곤 /Hyeong-Gon Moon 남석진 이정언 임우성 이미리 노동영 /Dong-Young Noh 한원식

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.18 No.1

발행연도: 2015.1

수록면: 8 - 15 (8page)

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Purpose: The aim of this study was to investigate whether theobserved changes over time in the survival rates vary accordingto the intrinsic subtypes of breast cancer diagnosed. Methods:Data from 46,320 breast cancer patients in the Korean BreastCancer Registry who underwent surgery between 1999 and2006 were reviewed. Among them, results from 25,887 patientswith available data about the status of estrogen receptor, progesteronereceptor, and human epidermal growth factor receptor2 (HER2) were analyzed. Patients were classified into two cohortsaccording to the year in which they underwent surgery:1999–2002 and 2003–2006. Results: The patients treated in thelatter time period showed significantly better overall survival (OS)compared with those in the former period when adjusted for follow-up duration. The proportion of hormone receptor+/HER2-subtype and stage I breast cancer were significantly higher inthe latter period (47.4% vs. 54.6%, p<0.001; 31.0% vs. 39.6%,p<0.001, respectively). Improvement in OS between the formerand latter periods was seen in all subtypes of breast cancer, includingtriple-negative cancers (all p-values <0.001 in univariateand multivariate analyses). Conclusion: Improvement in survivalin Korean breast cancer patients over the study years is beingobserved in all subtypes of breast cancer, implying that increasesin both early-stage detection and the proportion of less aggressivecancers contribute to this improvement.

#Breast neoplasms #Clinical characteristics #Korea #Registries

참고문헌 (15)

참고문헌 신청

고범석 / 2012 / Changing Patterns in the Clinical Characteristics of Korean Breast Cancer from 1996-2010 Using an Online Nationwide Breast Cancer Database / Journal of Breast Cancer 15(4):393~400

Korean Breast Cancer Society / 2002 / Clinical characteristics of breast cancer patients in Korea in year 2000 / Korean Breast Cancer Soc 5:217~224

The Korean Breast Cancer Society / 2004 / Nationwide Korean breast cancer data of 2002 The Korean Breast Cancer Society / J Korean Breast Cancer Soc 7:72~83

정용식 / 2011 / Nation-Wide Korean Breast Cancer Data from 2008 Using the Breast Cancer Registration Program / Journal of Breast Cancer 14(3):229~236

The Korean Breast Cancer Society / 2006 / Survival analysis of Korean breast cancer patients diagnosed between 1993 and 2002 in Korea : a nationwide study of the cancer registry / J Breast Cancer 9:214~229

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