지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 29 - 35 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: To investigate treatment options for local control of metastasisin the brain, we compared focal brain treatment (FBT)with or without whole brain radiotherapy (WBRT) vs. WBRT alone,for breast cancer patients with tumor relapse in the brain. We alsoevaluated treatment outcomes according to the subtypes. Methods:We conducted a retrospective review of breast cancer patientswith brain metastasis after primary surgery. All patients receivedat least one local treatment for brain metastasis. Surgeryor stereotactic radiosurgery was categorized as FBT. Patientswere divided into two groups: the FBT group received FBT±WBRT, whereas the non-FBT group received WBRT alone. Subtypeswere defined as follows: hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative, HRpositive/HER2-positive, HR-negative/HER2-positive, and triplenegative(TN). We examined the overall survival after brain metastasis(OSBM), brain metastasis-specific survival (BMSS), andbrain metastasis-specific progression-free survival (BMPFS). Results:A total of 116 patients were identified. After a median follow-up of 50.9 months, the median OSBM was 11.5 months(95% confidence interval, 9.0–14.1 months). The FBT groupshowed significantly superior OSBM and BMSS. However, FBTwas not an independent prognostic factor for OSBM and BMSSon multivariate analyses. In contrast, multivariate analysesshowed that patients who underwent surgery had improvedBMPFS, indicating local control of metastasis in the brain. FBTresulted in better BMPFS in patients with HR-negative/HER2-positive cancer or the TN subtype. Conclusion: We found that patientswho underwent surgery experienced improved local controlof brain metastasis, regardless of its extent. Furthermore, FBTshowed positive results and could be considered for better localcontrol of brain metastasis in patients with aggressive subtypessuch as HER2-positive and TN.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Siegel R / 2012 / Cancer treatment and survivorship statistics, 2012 / CA Cancer J Clin 62:220~241
Xue J / 2013 / Predictive factors of brain metastasis in patients with breast cancer / Med Oncol 30:337
정규원 / 2013 / Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 / Cancer Research and Treatment 45(1):1~14
Hofer S / 2013 / Treatment of breast cancer brain metastases / Eur J Pharmacol 717:84~87
Karam I / 2013 / Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the Pre-Trastuzumab and Trastuzumab eras / Radiat Oncol 8:12
Xue J / 2013 / Predictive factors of brain metastasis in patients with breast cancer / Med Oncol 30:337
정규원 / 2013 / Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 / Cancer Research and Treatment 45(1):1~14
Hofer S / 2013 / Treatment of breast cancer brain metastases / Eur J Pharmacol 717:84~87
Karam I / 2013 / Population-based outcomes after brain radiotherapy in patients with brain metastases from breast cancer in the Pre-Trastuzumab and Trastuzumab eras / Radiat Oncol 8:12
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Role of HER2 in Brain Metastasis of Breast Cancer: a Systematic Review and Meta-Analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
뇌전이를 동반한 간세포암종 환자에서 수술 절제 후 장기 생존을 보인 1예
Journal of Liver Cancer
2016 .01
-
Treatment Outcomes of Brain metastasis from Papillary Thyroid Cancer
대한 두경부 종양 학술지
2018 .01
-
Brain metastasis in human epidermal growth factor receptor 2-positive breast cancer: from biology to treatment
Radiation oncology journal : ROJ
2016 .01
-
Whole Brain Radiotherapy Combined with Stereotactic Radiosurgery versus Stereotactic Radiosurgery Alone for Brain Metastases
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Brain metastasis from colorectal cancer : a single center experience
Annals of Surgical Treatment and Research
2018 .01
-
Effective Treatment of Solitary Pituitary Metastasis with Panhypopituitarism in HER2-Positive Breast Cancer by Lapatinib
Cancer Research and Treatment
2016 .01
-
A National Consensus Survey for Current Practice in Brain Tumor Management III: Brain Metastasis and Primary Central Nervous System Lymphoma
Brain Tumor Research and Treatment
2020 .01
-
Efficacy of Surgical Treatment for Brain Metastasis in Patients with Non-Small Cell Lung Cancer
Yonsei Medical Journal
2015 .01
-
Verification of Low Risk for Perihippocampal Recurrence in Patients with Brain Metastases Who Received Whole-Brain Radiotherapy with Hippocampal Avoidance
Cancer Research and Treatment
2019 .01
-
Prognostic Factors in Patients with Non-small Cell Lung Carcinoma and Brain Metastases: a Malaysian Perspective
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Fractionated Stereotactic Radiosurgery for Brain Metastases Using the Novalis Tx<sup>®</sup> System
대한신경외과학회지
2018 .01
-
Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients
Cancer Research and Treatment
2017 .07
-
Brain Metastases from Solid Tumors: an Institutional Study from South India
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Oncologic outcomes following metastasectomy in colorectal cancer patients developing distant metastases after initial treatment
Annals of Surgical Treatment and Research
2015 .04
-
정신건강의학과 의사를 위한 뇌파의 기초
신경정신의학
2019 .01
-
Development of Efficient Brain Age Estimation Method Based on Regional Brain Volume From Structural Magnetic Resonance Imaging
PSYCHIATRY INVESTIGATION
2024 .01
-
원격전이가 발생한 폐경전 여성 유방암 환자에서의 예후인자
Journal of Breast Disease
2020 .01
-
Stereotactic radiosurgery for brain metastasis in non-small cell lung cancer
Radiation oncology journal : ROJ
2015 .01
-
Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide
Brain Tumor Research and Treatment
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0