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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 225 - 234 (10page)
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Purpose: The unmanageable side effects caused by current chemotherapy regimens to treat cancer are an unresolved problem. Although many phytonutrients are useful as chemoprevention without side effects, their effects are slower and smaller than conventional chemotherapy. In the present work, we examined the cumulative effect of two phytonutrients, curcumin and citral, on breast cancer cell lines and compared their effect with the known chemotherapy regimen of cyclophosphamide, methotrexate, and 5-fluorouracil. Methods: Using cultured breast cancer and normal epithelial cells, the cytotoxic and apoptotic effect of curcumin and citral was evaluated in vitro. The synergistic effect of curcumin and citral was calculated by a combination index study using the method by Chou and Talalay. Cell death pathways and mechanisms were analyzed by measuring intracellular reactive oxygen species (ROS) and apoptotic protein levels. Results: Curcumin and citral caused dose and time dependent cell death and showed a synergistic effect at effective concentration EC50 and above concentrations in breast cancer cells without disturbing normal breast epithelial cells. With combination curcumin and citral treatment, apoptosis induction and cell cycle arrest at G0/G1 phase in breast cancer cells were observed. Curcumin and citral generated ROS and activated p53 and poly (ADP-ribose) polymerase-1 (PARP) mediated apoptotic pathways. Conclusion: The results of this study suggest that curcumin and citral in combination may be a useful therapeutic intervention for breast cancer
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참고문헌 (26)
참고문헌 신청
Pan MH / 2008 / Chemopreventive effects of natural dietary compounds on cancer development / Chem Soc Rev 37:2558~2574
Lee SJ / 2011 / Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo / BMC Cancer 11:144
Ravindran J / 2009 / Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? / AAPS J 11:495~510
Ramachandran C / 1999 / Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin / Breast Cancer Res Treat 54:269~278
Shah G / 2011 / Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass) / J Adv Pharm Technol Res 2:3~8
Lee SJ / 2011 / Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo / BMC Cancer 11:144
Ravindran J / 2009 / Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? / AAPS J 11:495~510
Ramachandran C / 1999 / Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin / Breast Cancer Res Treat 54:269~278
Shah G / 2011 / Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass) / J Adv Pharm Technol Res 2:3~8
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