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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 242 - 248 (7page)
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Purpose: It is well established that breast cancer stem cells (BCSCs) play an essential role in tumor invasion for both local and distant metastasis. The aim of this study was to establish whether BCSCs could act as a prognostic and clinical marker. Methods: We analyzed tumor tissues from 161 breast cancer patients. Dual immunohistochemistry and immunofluorescence were performed on all the slides, and we analyzed the relationship between EpCAM–/CD49f+ tumor cells and key clinical and prognostic factors. Results: Univariate survival analysis using the Kaplan-Meier method showed that the presence of EpCAM–/ CD49f+ tumor cells in breast cancer was significantly associated with shorter disease-free survival (DFS) and overall survival (OS). Multivariate analysis showed that the presence of EpCAM–/ CD49f+ cells was associated with shorter DFS (p=0.010; hazard ratio [HR], 2.070) and OS (p=0.002; HR, 3.235). Tumors containing EpCAM–/CD49f+ cells were also more likely to metastasize after initial surgery (p=0.048). Conclusion: Our study suggests that breast tumors containing EpCAM–/CD49f+ cells are more likely to undergo distant metastasis after initial surgery and are associated with a shorter DFS and OS.
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참고문헌 (29)
참고문헌 신청
Weigelt B / 2010 / Histological types of breast cancer: how special are they? / Mol Oncol 4:192~208
Al-Hajj M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100:3983~3988
Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567
Basak SK / 2009 / The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer / PLoS One 4:e5884
Huang EH / 2009 / Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells(SC)and tracks SC overpopulation during colon tumorigenesis / Cancer Res 69:3382~3389
Al-Hajj M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100:3983~3988
Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567
Basak SK / 2009 / The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer / PLoS One 4:e5884
Huang EH / 2009 / Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells(SC)and tracks SC overpopulation during colon tumorigenesis / Cancer Res 69:3382~3389
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