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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 140 - 144 (5page)
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Coal workers’ pneumoconiosis (CWP) is characterized as a chronic inflammation of the lungassociated with activation of macrophages and endothelial cells in the lung. The aim of thepresent study was to compare the levels of serum interleukin-8 (IL-8), macrophageinflammatory protein-1α (MIP-α), and intercellular adhesion molecule-1 (ICAM-1) asbiomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWPpatients). The levels of serum IL-8 (P < 0.001) and ICAM-1 (P = 0.001) of subjects withPMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects werealso higher than those of simple CWP subjects (P = 0.003). Among the subjects withoutPMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II orIII were higher than those in the subjects with ILO category 0 (P = 0.006) and with category I(P = 0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which areimportant as neutrophil attractants and adhesion molecules, are associated with PMF.
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참고문헌 (26)
참고문헌 신청
Schins RP / 1999 / Mechanisms and mediators in coal dust induced toxicity : a review / Ann Occup Hyg 43:7~33
Vanhée D / 1996 / Expression of leucocyte-endothelial adhesion molecules is limited to intercellular adhesion molecule-1(ICAM-1)in the lung of pneumoconiotic patients : role of tumour necrosis factor-alpha(TNF-α) / Clin Exp Immunol 106:541~548
Soutar CA / 1984 / Classification of progressive massive fibrosis of coalminers by type of radiographic appearance / Br J Ind Med 41:334~339
Kelley J / 1990 / Cytokines of the lung / Am Rev Respir Dis 141:765~788
Wolpe SD / 1988 / Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties / J Exp Med 167:570~581
Vanhée D / 1996 / Expression of leucocyte-endothelial adhesion molecules is limited to intercellular adhesion molecule-1(ICAM-1)in the lung of pneumoconiotic patients : role of tumour necrosis factor-alpha(TNF-α) / Clin Exp Immunol 106:541~548
Soutar CA / 1984 / Classification of progressive massive fibrosis of coalminers by type of radiographic appearance / Br J Ind Med 41:334~339
Kelley J / 1990 / Cytokines of the lung / Am Rev Respir Dis 141:765~788
Wolpe SD / 1988 / Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties / J Exp Med 167:570~581
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