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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 625 - 631 (7page)
이용수
초록· 키워드
오류제보하기
Previous fMRI studies of sensorimotor activation in schizophrenia have found in some cases hypoactivity, no difference, or hyperactivity when comparing patients with controls; similar disagreement exists in studies of motor laterality. In this multi-site fMRI study of a sensorimotor task in individuals with chronic schizophrenia and matched healthy controls, subjects responded with a right-handed finger press to an irregularly flashing visual checker board. The analysis includes eighty-five subjects with schizophrenia diagnosed according to the DSM-IV criteria and eighty-six healthy volunteer subjects. Voxel-wise statistical parametric maps were generated for each subject and analyzed for group differences; the percent Blood Oxygenation Level Dependent (BOLD) signal changes were also calculated over predefined anatomical regions of the primary sensory, motor, and visual cortex. Both healthy controls and subjects with schizophrenia showed strongly lateralized activation in the precentral gyrus, inferior frontal gyrus, and inferior parietal lobule, and strong activations in the visual cortex. There were no significant differences between subjects with schizophrenia and controls in this multi-site fMRI study.
Furthermore, there was no significant difference in laterality found between healthy controls and schizophrenic subjects. This study can serve as a baseline measurement of schizophrenic dysfunction in other cognitive processes.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Mamah D / 2007 / Csernansky JG. Structural analysis of the basal ganglia in schizophrenia / Schizophr Res 89:59~71
정위훈 / 2010 / Structural Brain Alterations in Individuals at Ultra-high Risk for Psychosis: A Review of Magnetic Resonance Imaging Studies and Future Directions / Journal of Korean Medical Science 25(12):1700~1709
Aleman A / 1999 / Memory impairment in schizophrenia: a meta-analysis / Am J Psychiatry 156:1358~1366
Günther W / 1991 / Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging / Biol Psychiatry 29:535~555
Nuechterlein KH / 1977 / Reaction time and attention in schizophrenia : a critical evaluation of the data and theories / Schizophr Bull 3:373~428
정위훈 / 2010 / Structural Brain Alterations in Individuals at Ultra-high Risk for Psychosis: A Review of Magnetic Resonance Imaging Studies and Future Directions / Journal of Korean Medical Science 25(12):1700~1709
Aleman A / 1999 / Memory impairment in schizophrenia: a meta-analysis / Am J Psychiatry 156:1358~1366
Günther W / 1991 / Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging / Biol Psychiatry 29:535~555
Nuechterlein KH / 1977 / Reaction time and attention in schizophrenia : a critical evaluation of the data and theories / Schizophr Bull 3:373~428
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