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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,821 - 1,827 (7page)
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Whether nonalcoholic fatty liver disease (NAFLD) is related to vitamin D and bone health in obese children is unknown. The aim of this study was to evaluate vitamin D status and bone mineral density (BMD) in obese children according to their condition within the NAFLD spectrum. Anthropometric data, laboratory tests, and abdominal ultrasonography were obtained from 94 obese children. The subjects were divided into three groups according to NAFLD spectrum: normal liver, simple steatosis, and nonalcoholic steatohepatitis (NASH). Although there were no differences in vitamin D levels between the three groups, these groups showed significant differences in highly sensitive C-reactive protein (P = 0.044), homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.02), hepatic fibrosis scores (P < 0.05), and trunk fat percentage (P = 0.025). Although there were significant differences in BMDs, the age-matched BMD z-scores were not significantly different between the three groups. Serum vitamin D levels were negatively correlated with age (r = -0.368, P = 0.023), serum uric acid levels (r = -0.371, P = 0.022), fibrosis 4 (FIB4) (r = -0.406, P = 0.011), and HOMA-IR (r = -0.530, P = 0.001) in obese children with NASH. Multiple regression analysis for vitamin D in the NASH group revealed age and HOMA-IR as significant factors. In conclusion, inflammatory markers, hepatic fibrosis scores, trunk fat, and insulin resistance may reflect the spectrum of NAFLD in obese children, whereas vitamin D levels and BMD may not. In patients with NASH, however, low serum vitamin D is associated with hepatic fibrosis and insulin resistance, but not with bone health status.
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참고문헌 (21)
참고문헌 신청
Bugianesi E / 2002 / Expanding the natural history of nonalcoholic steatohepatitis : from cryptogenic cirrhosis to hepatocellular carcinoma / Gastroenterology 123:134~140
양혜란 / 2014 / Comparison between a Pediatric Health Promotion Center and a Pediatric Obesity Clinic in Detecting Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease in Children / Journal of Korean Medical Science 12(12):1672~1677
Barshop NJ / 2008 / Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease / Aliment Pharmacol Ther 28:13~24
Schwimmer JB / 2006 / Prevalence of fatty liver in children and adolescents / Pediatrics 118:1388~1393
Binkley N / 2010 / Low vitamin D status: definition, prevalence, consequences, and correction / Endocrinol Metab Clin North Am 39:287~301
양혜란 / 2014 / Comparison between a Pediatric Health Promotion Center and a Pediatric Obesity Clinic in Detecting Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease in Children / Journal of Korean Medical Science 12(12):1672~1677
Barshop NJ / 2008 / Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease / Aliment Pharmacol Ther 28:13~24
Schwimmer JB / 2006 / Prevalence of fatty liver in children and adolescents / Pediatrics 118:1388~1393
Binkley N / 2010 / Low vitamin D status: definition, prevalence, consequences, and correction / Endocrinol Metab Clin North Am 39:287~301
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