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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 214 - 218 (5page)
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초록· 키워드
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Background: Critical illness that requires major surgery is often associated with non-thyroidal illness syndrome (NTIS). The characteristic feature of NTIS is low serum triiodothyronine (T3) levels, and in severe illness, the levels of serum thyroxine (T4) are also low in the absence of a rise in thyroid stimulating hormone (TSH). However, little is known about the changes in thyroid hormones during and after liver transplantation (LT). This study was conducted in order to evaluate the intra- or postoperative changes in thyroid hormones. Methods: Twenty-two patients who underwent LT were enrolled. Serum levels of triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), free T3 (FT3) and free T4 (FT4) were measured immediately after the induction of anesthesia (T1), at the end of the anhepatic period (T2), at the end of the surgical procedure (T3), and at 24 hours (T4) and 120 hours postoperatively (T5). Results: The mean levels of T3, T4, FT3, FT4 and TSH were significantly decreased throughout the study when compared with the T1 value. The mean levels of T3, T4 FT3 and TSH were below the normal range from T2, T4 and T5. Conclusions: We suggest that LT may induce NTIS by at least postoperative day 5. In the future, longer follow-up studies, and the effects of thyroid hormones on the prognosis and determination of the advantages and disadvantages of T3 replacement therapy to these patients will be required.
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참고문헌 (20)
참고문헌 신청
Cerillo AG / 2005 / The non-thyroidal illness syndrome after coronary artery bypass grafting: a 6-month follow-up study / Clin Chem Lab Med 43:289~293
Velissaris T / 2009 / Thyroid function during coronary surgery with and without cardiopulmonary bypass / Eur J Cardiothorac Surg 36:148~154
Rodriguez-Perez A / 2008 / Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock / Clin Endocrinol 68:821~827
Karga H / 2000 / The role of cytokines and cortisol in the non-thyroidal illness syndrome following acute myocardial infarction / Eur J Endocrinol 142:236~242
Boelen A / 2008 / Fasting-induced changes in the hypothalamus-pituitary-thyroid axis / Thyroid 18:123~129
Velissaris T / 2009 / Thyroid function during coronary surgery with and without cardiopulmonary bypass / Eur J Cardiothorac Surg 36:148~154
Rodriguez-Perez A / 2008 / Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock / Clin Endocrinol 68:821~827
Karga H / 2000 / The role of cytokines and cortisol in the non-thyroidal illness syndrome following acute myocardial infarction / Eur J Endocrinol 142:236~242
Boelen A / 2008 / Fasting-induced changes in the hypothalamus-pituitary-thyroid axis / Thyroid 18:123~129
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