지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 574 - 581 (8page)
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초록· 키워드
오류제보하기
Background: Postoperative thyroid stimulating hormone (TSH) suppression therapy is recommended for patients with intermediate- and high-risk differentiated thyroid cancer to prevent the recurrence of thyroid cancer. With the recent increase in small thyroidcancer cases, the extent of resection during surgery has generally decreased. Therefore, questions have been raised about the efficacy and long-term side effects of TSH suppression therapy in patients who have undergone a lobectomy. Methods: This is a multicenter, prospective, randomized, controlled clinical trial in which 2,986 patients with papillary thyroid cancer are randomized into a high-TSH group (intervention) and a low-TSH group (control) after having undergone a lobectomy. Theprinciple of treatment includes a TSH-lowering regimen aimed at TSH levels between 0.3 and 1.99 μIU/mL in the low-TSH group. The high-TSH group targets TSH levels between 2.0 and 7.99 μIU/mL. The dose of levothyroxine will be adjusted at each visit to maintain the target TSH level. The primary outcome is recurrence-free survival, as assessed by neck ultrasound every 6 to 12months. Secondary endpoints include disease-free survival, overall survival, success rate in reaching the TSH target range, the proportion of patients with major cardiovascular diseases or bone metabolic disease, the quality of life, and medical costs. The followup period is 5 years. Conclusion: The results of this trial will contribute to establishing the optimal indication for TSH suppression therapy in low-risk papillary thyroid cancer patients by evaluating the benefit and harm of lowering TSH levels in terms of recurrence, metabolic complications, costs, and quality of life.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Kitahara CM / 2016 / The changing incidence of thyroid cancer / Nat Rev Endocrinol 12:646~653
Lee YS / 2016 / Changing trends in the management of well-differentiated thyroid carcinoma in Korea / Endocr J 63:515~521
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133
이가희 / 2016 / 2016년 대한갑상선학회 갑상선결절 및 암 진료 권고안 개정안 / International Journal of Thyroidology 9(2):59~126
Simpson WJ / 1988 / Papillary and follicular thyroid cancer : impact of treatment in 1578 patients / Int J Radiat Oncol Biol Phys 14:1063~1075
Lee YS / 2016 / Changing trends in the management of well-differentiated thyroid carcinoma in Korea / Endocr J 63:515~521
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133
이가희 / 2016 / 2016년 대한갑상선학회 갑상선결절 및 암 진료 권고안 개정안 / International Journal of Thyroidology 9(2):59~126
Simpson WJ / 1988 / Papillary and follicular thyroid cancer : impact of treatment in 1578 patients / Int J Radiat Oncol Biol Phys 14:1063~1075
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