지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 178 - 188 (11page)
이용수
초록· 키워드
오류제보하기
Primary infection of varicella-zoster virus (VZV) causes varicella and often leads to zoster after reactivation from latency. Both varicella and zoster can be prevented by live attenuated vaccines, but the molecular mechanism of attenuation is not clearly understood. In this study, it was attempted to understand mechanism of attenuating mutation in VZV by in vitro propagation in non-natural conditions such as low temperature or non-human cell. Clinical strain YC02 was subcultured in vitro up to 60 times. Comparison of the genome sequences of YC02 variants cultured under various conditions identified specific mutations occurred in non-natural conditions. The mutations specific for low temperature culture and non-human cell culture were identified in 8 and 2 positions, respectively. Two vaccine-specific mutations in position 97748 and 106262 were identified during subculture in non-natural conditions. Genetic diversity as measured by genetic polymorphism and Shannon entropy decreased when cultured in guinea pig lung cell culture. The infectivity of YC02 cultured at low temperature appeared similar to that cultured in natural condition. On the other hands, infectivity decreased significantly when YC02 was subcultured in non-human cell. Further studies on mutations and genetic diversity of clinical strain cultured in non-natural conditions will help to elucidate the molecular mechanism of VZV attenuation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
Discussion
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genetic Diversity among Varicella-Zoster Virus Vaccine Strains
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .06
-
Immune Responses to Varicella Zoster Virus and Effective Vaccines
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .09
-
Mutations in Varicella Zoster Virus Following In Vitro Passaging
한국미생물학회 학술대회논문집
2015 .04
-
비전형적 DNA 이차구조 G-quadruplex에 의한 Varicella-Zoster Virus 유전자 발현의 조절
한국미생물학회 학술대회논문집
2018 .04
-
G-Quadruplexes Formed by Varicella-Zoster Virus Reiteration Sequences Suppress Expression of Glycoprotein C and Regulate Viral Cell-to-cell Spread
한국미생물학회 학술대회논문집
2022 .10
-
Inhibition of Varicella-zoster Virus Replication by the Extract from Elaeocarpus sylvestris
한국미생물학회 학술대회논문집
2016 .04
-
Measurement of Antibodies to Varicella-Zoster Virus Using a Virus-Free Fluorescent-Antibody-to-Membrane-Antigen (FAMA) Test
Journal of Microbiology and Biotechnology
2015 .01
-
Bacillus oryzicola sp. nov., an Endophytic Bacterium Isolated from the Roots of Rice with Antimicrobial, Plant Growth Promoting, and Systemic Resistance Inducing Activities in Rice
The Plant Pathology Journal
2015 .06
-
Continuous Passaging of a Recombinant C-Strain Virus in PK-15 Cells Selects Culture-Adapted Variants that Showed Enhanced Replication but Failed to Induce Fever in Rabbits
Journal of Microbiology and Biotechnology
2017 .01
-
Insertional mutations exhibiting high cell-culture density HCD phenotypes are enriched through continuous subcultures in Chlamydomonas reinhardtii
Algae
2018 .01
-
Identification of novel alleles induced by EMS-mutagenesis in key genes of kernel hardness and starch biosynthesis in wheat by TILLING
Genes & Genomics
2017 .01
-
Generation of a High-Growth Influenza Vaccine Strain in MDCK Cells for Vaccine Preparedness
Journal of Microbiology and Biotechnology
2018 .01
-
D614G Mutation in RBD Increases the Infectivity of SARS-CoV-2
한국미생물학회 학술대회논문집
2021 .08
-
Development of Spectinabilin Over-productivity Mutant Strain by a Genetic Mutation
한국미생물학회 학술대회논문집
2022 .10
-
Development of the Chimeric ZIKA Virus Vaccine Using SA14-14-2, Attenuated Japanese Encephalitis Virus Vaccine Strain
한국미생물학회 학술대회논문집
2017 .04
-
Biological Control of Rice Bakanae by an Endophytic Bacillus oryzicola YC7007
The Plant Pathology Journal
2016 .06
-
Brain Somatic Mutations in Epileptic Disorders
Molecules and Cells
2018 .10
-
The First-principles Calculations on the Half-metallic Properties of (001) and (110) Surfaces of Zinc-blende YC
Journal of Magnetics
2015 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2022-475-000131665