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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 199 - 200 (2page)
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초록· 키워드
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Magnetic nanoparticles (MNPs, Fe₃O₄) are getting a lot of attention as substances widely applied in medical/science fields such as separation of cells, genetic cloning, biosensor, magnetic resonance imaging (MRI), etc for use biomolecular diagnosis and biological application. In a very serious pandemic situation around the world, even after vaccination, coronavirus disease 2019 (COVID-19) treatments for cytokine inhibition has cytokine receptor inhibition and specific immune cell depletion other than steroid hormone. Among them there is a monoclonal antibody (mAb) treatment among the methods of depletion of specific immune cells. Monoclonal antibody treatment is a way that inhibits cytokine secretion by inhibiting cluster of differentiation 3 (CD3) that is one of the important signaling molecules for activation of T cell receptors. An optimal Fc-directed conjugate of humanized anti-CD3 monoclonal antibody (Foralumab) and amine group-MNPs was prepared by the SiteClick antibody labeling kit. The SiteClick antibody labeling kit, which includes antibody control, buffer exchange, antibody carbohydrate domain modification, azide attachment, and azide-modified antibody purification ... 전체 초록 보기
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