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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 173 - 178 (6page)
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초록· 키워드
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We investigated the efficacy of single compound of plant extract in coxsackievirus B3 (CVB3) infection. CVB3 is a main cause of Hand-foot-mouth diseases (HFMD) and viral myocarditis in children and adult. Several single compounds of plant extract were purified by HPLC and tested as antiviral drug candidate. Among them, kaempferol was selected to effective anti-enterovirus compound by HeLa cells survival assay. CVB3 infected HeLa cells were treated with kaempferol (100 μg/ml-100 ng/ml) and their antiviral effect was confirmed. After 16 hours of treatment, HeLa cells were lysed and proteins were extracted for western blot analysis. CVB3 viral capsid protein VP1 production and transcription factor eIF4G-1 cleavage was significantly decreased in 100 μg/ml kaempferol treatment. Virus replication was observed by virus RNA amplification. Kaempferol strongly reduced virus positive and negative strand RNA amplification. Moreover, MAPK signal induced by CVB3 infection, pERK and pmTOR, kaempferol treatment significantly inhibited the activity. Plant extract single compound, kaempferol, is a strong candidate to be developed non-toxic anti-enterovirus treatment agent.
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참고문헌 (24)
참고문헌 신청
Feldman, A. M. / 2000 / Myocarditis / N. Engl. J. Med 343:1388~1398
Lim, B. K. / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest. 118:2758~2770
Knowlton, K. U. / 1996 / A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3 / J. Virol. 70:7811~7818
Knowlton, K. U. / 1999 / The immune system in viral myocarditis: maintaining the balance / Circ. Res. 85:559~561
Xiong, D. / 2007 / Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy / Circulation 115:94~102
Lim, B. K. / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / J. Clin. Invest. 118:2758~2770
Knowlton, K. U. / 1996 / A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3 / J. Virol. 70:7811~7818
Knowlton, K. U. / 1999 / The immune system in viral myocarditis: maintaining the balance / Circ. Res. 85:559~561
Xiong, D. / 2007 / Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy / Circulation 115:94~102
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