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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 65 - 69 (5page)
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초록· 키워드
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Torilin is a major sesquiterpene of Torilis japonica (Umbelliferae) fruits and known to be a melanogenesis inhibitor. Extraction conditions are important factor for the efficient preparation to save cost and time in economic aspects. For this reason, this study was conducted to optimize the extraction condition for maximal yield of torilin. For optimization, extraction factors such as extraction solvent, extraction temperature and sample/solvent ratio were tested and optimized for maximum yield of torilin using response surface methodology with Box-Behnken design (BBD). The optimal condition was obtained as a EtOAc concentration in MeOH of 31.8%, an extraction temperature at 30.3oC and a sample/solvent ratio, 1000 mg/2 ml. The torilin yield under optimal conditions was found to be 9.9 mg/g dried samples, which were well-matched with the predicted value of 10.4 mg/g dried samples. These results will provide useful information about optimized extraction conditions for the development of torilin as cosmetic therapeutics to reduce skin hyperpigmentation.
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참고문헌 (18)
참고문헌 신청
배기환 / 2000 / 한국의 약용식물 / 교학사 :213
Endale, M. / 2013 / Torilin ameliorates type II collageninduced arthritis in mouse model of rheumatoid arthritis / Int. Immunopharmacol. 16:232~242
박혜원 / 2006 / Guaiane Sesquiterpenoids from Torilis japonica and Their Cytotoxic Effects on Human Cancer Cell Lines / Archives of Pharmacal Research 29(2):131~134
Choi, Y. / 2009 / Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1${\beta}$ by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells / Br. J. Pharmacol. 156:933~940
Youn, H. J. / 2004 / Anti-protozoal efficacy of high performance liquid chromatography fractions of Torilis japonica and Sophora flavescens extracts on Neospora caninum and Toxoplasma gondii / Vet. Parasitol. 25:409~414
Endale, M. / 2013 / Torilin ameliorates type II collageninduced arthritis in mouse model of rheumatoid arthritis / Int. Immunopharmacol. 16:232~242
박혜원 / 2006 / Guaiane Sesquiterpenoids from Torilis japonica and Their Cytotoxic Effects on Human Cancer Cell Lines / Archives of Pharmacal Research 29(2):131~134
Choi, Y. / 2009 / Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1
Youn, H. J. / 2004 / Anti-protozoal efficacy of high performance liquid chromatography fractions of Torilis japonica and Sophora flavescens extracts on Neospora caninum and Toxoplasma gondii / Vet. Parasitol. 25:409~414
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