지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 345 - 350 (6page)
- DOI
- 10.20307/nps.2020.26.4.345
이용수
초록· 키워드
오류제보하기
In recent years, tyrosine kinases (TKs) have been the target to combat cancers, and most of the developed inhibitors are of synthetic origin. Natural compounds that have the properties as the TK’s inhibitors are very limited. This paper described the isolation of a new dammarane triterpene from the tree bark of Sandoricum koetjape, along with three known related dammaranes from the damar resin of Shorea javanica, as well as their inhibitory properties against eight receptor TKs (RTKs: EGFR, HER2, HER4, IGF1R, InsR, KDR, PDGFRα, and PDGFRβ). Based on the NMR and mass spectral data the new compound was identified as (12β,20S)-12,20-dihydroxy-3,4-seco-dammaran-4,24-dien-3-oic acid (12β-hydroxydammarenolic acid) (1), while the three known compounds were identified as (20S)-20-hydroxy-3,4-seco-dammaran-4,24-dien-3-oic acid (dammarenolic acid) (2), (3β,20S)-3,20-dihydroxydammaran-24-ene (3), and (20S)-3-oxo-20-hydroxydammaran-24-ene (4). The tyrosine kinase assay of the four compounds resulted only 1 and 2 at concentration of 10 μM that had weak activity against EGFR and InsR, with their % inhibitory were 30%, 27% (1), 45%, and 32% (2), respectively. The results suggested that the presence of a linear carboxylic acid group in both compounds could be of significance to the inhibitory properties against the two RTKs.
목차
Abstract
Introduction
Experimental
Result and Discussion
References
참고문헌 (23)
참고문헌 신청
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Cipadesin Limonoid and a Tirucallane Triterpene from the Fruit of Sandoricum koetjape and their Inhibitory Properties against Receptor Tyrosine Kinases
Natural Product Sciences
2021 .06
-
New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng
Journal of Ginseng Research
2020 .05
-
Six new dammarane-type triterpene saponins from Panax ginseng flower buds and their cytotoxicity
Journal of Ginseng Research
2020 .03
-
Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root
Journal of Ginseng Research
2017 .10
-
Identification of a Novel Function of Extract of Gingko biloba (EGb 761®) as a Regulator of PYY Secretion and FFA4 Activation
Natural Product Sciences
2019 .06
-
Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β‐cell apoptosis
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance and Strategies to Overcome Resistance in Lung Adenocarcinoma
Tuberculosis and Respiratory Diseases
2016 .01
-
목천료의 RAW264.7과 BV2 세포주에서의 일산화질소 생성 억제효과 트리테르펜
생약학회지(Korean Journal of Pharmacognosy)
2017 .06
-
CORRIGENDUM: CORRECTION OF TEXT. 진행성 갑상선암 환자에서 발생하는 Tyrosine Kinase Inhibitor의 이상반응
International Journal of Thyroidology
2019 .01
-
방사성요오드 불응성 갑상선암에서 티로신키나아제억제제 투여로 유발된 중증 피로감의 관리
International Journal of Thyroidology
2018 .01
-
Metastatic Squamous Cell Carcinoma from Lung Adenocarcinoma after Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy
Journal of Pathology and Translational Medicine
2017 .07
-
Gray Hair Associated with the Multitargeted Receptor Tyrosine Kinase Inhibitor Pazopanib
Annals of Dermatology
2015 .01
-
Plant Phenolics Ferulic Acid and P-Coumaric Acid Inhibit Colorectal Cancer Cell Proliferation through EGFR Down-Regulation
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Clinical Characteristics and Continued Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Administration in EGFR-Mutated Non-small Cell Lung Cancer with Skeletal Metastasis
Cancer Research and Treatment
2016 .01
-
EGFR C797S as a Resistance Mechanism of Lazertinib in Non-small Cell Lung Cancer with EGFR T790M Mutation
Cancer Research and Treatment
2020 .01
-
B세포림프종의 임상적 악성도 표지자로서 혈청 Thymidine Kinase 1의 유용성
Laboratory Medicine Online
2016 .01
-
Chemical Constituents of Nauclea vanderguchtii
Natural Product Sciences
2020 .06
-
High rate of hepatitis B reactivation during tyrosine kinase inhibitor treatment among patients with chronic myeloid leukemia in Korea
Blood Research
2022 .12
-
Efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors for patient with leptomeningeal metastasis of epidermal growth factor receptor mutant non-small cell lung cancer
영남의대학술지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0