지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 165 - 171 (7page)
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초록· 키워드
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Although the functions of a standardized extract of Gingko biloba leaves (EGb 761<SUP>®</SUP>) has been reported with regard to neurobiological properties, no attention has been paid to the impact of EGb 761<SUP>®</SUP> on the neuronal regulation of energy homeostasis. To evaluate the hypothesis that EGb 761<SUP>®</SUP> affect the secretion of peptide tyrosine tyrosine (PYY) and the activation of free fatty acid receptor 4 (FFA4), which are involved in the neuronal circuitries that control energy homeostasis by inducing the transfer of information about the influx of energy to the brain, we examined whether EGb 761<SUP>®</SUP> can stimulate PYY secretion in the enteroendocrine NCIH716 cells and if EGb 761<SUP>®</SUP> can activate FFA4 in FFA4-expressing cells. In NCI-H716 cells, EGb 761<SUP>®</SUP> stimulated PYY secretion and the EGb 761<SUP>®</SUP>-induced PYY secretion was involved in the increase in intracellular Ca<SUP>2+</SUP> concentration and the activation of FFA4. Furthermore, in FFA4-expressing cells, EGb 761<SUP>®</SUP> activated FFA4. These results suggest that EGb 761<SUP>®</SUP> may affect the control of energy homeostasis via the regulation of PYY secretion and FFA4 activation.
목차
Abstract
Introduction
Experimental
Results
Discussion
References
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