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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 170 - 176 (7page)
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Anthocyanins are considered as one of the major functional components including cyanidin-3-glucoside and peonidin-3-glucoside anthocyanins of black rice (Oryza sativa L., BR) aleurone layer (OAL) extract. The immunomodulatory biological effects of OAL has rarely been evaluated. This study has extensively studied the immunomodulatory effects of BR in immunosuppressed mice by CPA. The immunostimulatory effects of BR extract in in vivo at 150 (OAL-1) and 300 mg/kg body weight (OAL-2) for OAL groups were measured and compared to the normal group (CON) ingested with distilled water only or other groups. After the 14 days of oral administration, immune related organ weights, serum immunoglobulin (Ig) A and IgG, and cytokines (IL-12, TNF-α) levels, splenocytes proliferation rate, and NK cell activity were evaluated as immune related biomarkers. The serum IgA and IgG values in the OAL-treated groups increased to the level of the CON. OAL significantly and effectively controlled the IL-12 and TNF-α levels and NK activity compared to the negative control (NC) group. The results suggest that BR aleurone layer with immunomodulatory activities has a great potential as a functional food by itself or as a supplement.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (34)
참고문헌 신청
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World Health Organization / 2020 / International guidelines for certification and classification (coding) of COVID-19 as cause of death / International Statistical Classification of Diseases
Sujono, T. A. / 2021 / Effects of Jamaican cherry (Muntingia calabura L.)Fruits Extract on Immunoglobulin G Levels and Hematological Profiles in Mice / Pharmacogn. J 13:535~541
Gonzalez-Rey, E. / 2007 / Regulation of immune tolerance by anti-inflammatory neuropeptides / Nat. Rev. Immunol 7:52~63
Shirani, K. / 2015 / Phytotrapy of cyclophosphamide-induced immunosuppression / Environ. Toxicol. Pharmacol 39:1262~1275
World Health Organization / 2020 / International guidelines for certification and classification (coding) of COVID-19 as cause of death / International Statistical Classification of Diseases
Sujono, T. A. / 2021 / Effects of Jamaican cherry (Muntingia calabura L.)Fruits Extract on Immunoglobulin G Levels and Hematological Profiles in Mice / Pharmacogn. J 13:535~541
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