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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 340 - 348 (9page)
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This study was conducted to evaluate the immunomodulatory effects of red doraji (Platycodon grandiflorum, RD) prepared by repeated steaming and drying process in the immune-suppressed mice induced by pre (RD-A) or post-treatment (RD-B) with cyclophosphamide. The immune-stimulating effects of ethanol RD extract in in vivo at 150 (RD-1) and 300 mg/kg body weight (RD-2) for RD-A and RD-B groups were measured and compared to the NC group supplied with distilled water only or positive control group. After 14 days of oral supplement, serum IgA, IgG, and cytokine levels, splenocytes proliferation rate, NK cell activity, and gene expression of cytokines were measured as immune related biomarkers. Serum IgA, IgG, IL-1β, and IL-12 levels increased in both RD-A and RD-B groups while serum TNF- level decreased in RD-A group compared to the NC group. Splenocytes proliferation rate, NK cell activity, and cytokine (IL-1β, IL-6, IFN-γ) expression levels were also improved by RD supplement in the both groups. The RD showed more significant immunomodulatory effects at higher dose (RD-2) rather than the lower dose (RD-1). Thus, RD has an immune efficacy in a dose dependent manner and can be used as an immune stimulating source to improve immunity.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
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참고문헌 (36)
참고문헌 신청
Delves, P. J. / 2000 / The immune system / N. Engl. J. Med 343:37~49
McDade, T. W. / 2016 / Trade-offs between acquired and innate immune defenses in humans / Evol. Med. Public Health 2016:1~16
Li, X. / 2020 / Molecular immune pathogenesis and diagnosis of COVID19 / J. Pharm. Anal 10:102~108
Ilangkovan, M. / 2015 / Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats / Drug Des. Devel. Ther 9:4917
Da Hye Kwon / 2016 / The Immunomodulatory Activity of Mori folium, the Leaf of Morus alba L., in RAW 264.7 Macrophages In Vitro / 대한암예방학회지 21(3):144~151
McDade, T. W. / 2016 / Trade-offs between acquired and innate immune defenses in humans / Evol. Med. Public Health 2016:1~16
Li, X. / 2020 / Molecular immune pathogenesis and diagnosis of COVID19 / J. Pharm. Anal 10:102~108
Ilangkovan, M. / 2015 / Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats / Drug Des. Devel. Ther 9:4917
Da Hye Kwon / 2016 / The Immunomodulatory Activity of Mori folium, the Leaf of Morus alba L., in RAW 264.7 Macrophages In Vitro / 대한암예방학회지 21(3):144~151
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