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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 231 - 237 (7page)
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Euchrestaflavanone B (EFB) is a flavonoid that can be found in root bark, particularly in Cudrania tricuspidata (C. tricuspidata). The extract of C. tricuspidata is widespread throughout Asia and used in traditional medicine. In a previous study, we found anti-platelet effects of substances isolated from C. tricuspidata on collagen-induced human platelets. However, the C. tricuspidata still contains numerous substances, thus, we have searched new candidate, EFB isolated from C. tricuspidata for anti-platelet effect. Our results showed that EFA inhibited collagen-induced platelet aggregation and glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling events, including platelet adhesion, granule secretion, thromboxane A₂ production and clot retraction. These results suggest that EFA has inhibitory effects on human platelet activities and thrombus formation and has potential value as a natural substance for preventing platelet-induced thrombosis.
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Abstract
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참고문헌 (17)
참고문헌 신청
Jackson, S. P. / 2011 / Arterial thrombosis-insidious, unpredictable and deadly / Nature Medicine 17:1423~1436
Nishikawa, M. / 1980 / Ca2+-calmodulin-dependent phosphorylation and platelet secretion / Nature 287:863~865
Berridge, M. J. / 1984 / Inositol trisphosphate, a novel second messenger in cellular signal transduction / Nature 312:315~321
Phillips, D. R. / 2001 / Beta3 tyrosine phosphorylation in alphaIIb beta3(platelet membrane GPIIb-IIIa)outside-in integrin signaling / Thromb. Haemost 86:246~258
Needleman, P. / 1976 / Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides / Nature 261:558~556
Nishikawa, M. / 1980 / Ca2+-calmodulin-dependent phosphorylation and platelet secretion / Nature 287:863~865
Berridge, M. J. / 1984 / Inositol trisphosphate, a novel second messenger in cellular signal transduction / Nature 312:315~321
Phillips, D. R. / 2001 / Beta3 tyrosine phosphorylation in alphaIIb beta3(platelet membrane GPIIb-IIIa)outside-in integrin signaling / Thromb. Haemost 86:246~258
Needleman, P. / 1976 / Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides / Nature 261:558~556
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