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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 368 - 372 (5page)
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초록· 키워드
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We report the terahertz time-domain spectroscopy (THz-TDS) of transdermal drug delivery in human skin. The time evolution of transdermal nicotine delivery in nicotine patches was assessed by detecting the transmission coefficient of sub-picosecond THz pulses and using a semi-analytic model based on the single-layer effective medium approximation. Using commercial nicotine patches (Nicoderm CQ<SUP>®</SUP>, 7 mg/24 h), THz transmission coefficients were measured to quantitatively analyze the cumulative amounts of nicotine released from the patches in the absence of their detailed specifications, including multilayer structures and optical properties at THz frequencies. The results agreed well with measurements by conventional in vitro and in vivo methods, using a diffusion cell with high-performance liquid chromatography and blood sampling respectively. Our study revealed the ability of the THz-TDS method to be an effective alternative to existing methods for noninvasive and label-free assessments of transdermal drug delivery, showing its high promise for biomedical, pharmaceutical, and cosmetic applications.
목차
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND EXPERIMENT
Ⅲ. RESULTS AND DISCUSSION
Ⅳ. CONCLUSION
REFERENCES
참고문헌 (19)
참고문헌 신청
R. M. Woodward / 2003 / Terahertz pulse imaging of ex vivo basal cell carcinoma / J. Invest. Dermatol 120:72~78
S. W. Smye / 2001 / The interaction between Terahertz radiation and biological tissue / Phys. Med. Biol 46:R101
E. Jung / 2012 / Quantitative analysis of water distribution in human articular cartilage using terahertz time-domain spectroscopy / Biomed. Opt. Express 3:1110~1115
E. Jung / 2012 / THz timedomain spectroscopic imaging of human articular cartilage / J. Infrared, Millimeter, Teraherz Waves 33:593~598
Euna Jung / 2011 / Terahertz Pulse Imaging of Micro-metastatic Lymph Nodes in Early-stage Cervical Cancer Patients / Current Optics and Photonics 15(2):155~160
S. W. Smye / 2001 / The interaction between Terahertz radiation and biological tissue / Phys. Med. Biol 46:R101
E. Jung / 2012 / Quantitative analysis of water distribution in human articular cartilage using terahertz time-domain spectroscopy / Biomed. Opt. Express 3:1110~1115
E. Jung / 2012 / THz timedomain spectroscopic imaging of human articular cartilage / J. Infrared, Millimeter, Teraherz Waves 33:593~598
Euna Jung / 2011 / Terahertz Pulse Imaging of Micro-metastatic Lymph Nodes in Early-stage Cervical Cancer Patients / Current Optics and Photonics 15(2):155~160
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