지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
As the use of e-liquid cigarettes is rapidly increasing worldwide, it multiplies the potential risk undisclosed to the health of non- and smokers. To reduce the hazard, each country has its own set of regulations for controlling e-liquids. In Korea, the narrow definition of tobacco makes it difficult and have been steadily occurring tax evasion exploiting the difference in natural and artificial nicotine. Therefore, it is very important to distinguish source of nicotine for their regulation. To find biochemical discriminant markers, this study established analysis methods based on high-performance liquid chromatography coupled with diode array detector (HPLC-DAD) and high-performance liquid chromatography coupled with triple Quadrupole mass spectrometry (HPLC-MS/MS) for nicotine enantiomers and tobacco alkaloids targeted using the difference in pathways of nicotine biosynthesis and chemical synthesis. The method was validated by experimenting linearity (R² ＞ 0.999), recovery (80.99-108.41 %), accuracy (94.11-109.73 %) and precision (0.04-8.27 %). Then, the results for discrimination of the nicotine obtained from analysis of 65 commercial e-liquid products available in Korean market was evaluated. The method successfully applied to the e-liquids and one sample labelled ‘synthetic nicotine’ for tax exemption was found to contain a natural nicotine product. This method can be used to determine whether an e-liquid product uses natural or artificial nicotine and monitor non-taxable eliquid products. The method is more scientific than the existing one, which relies only on field evidence.
목차
Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
참고문헌 (19)
참고문헌 신청
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N. Prévôt, De F. Oliveira, S. Perinel-Ragey, T. Basset, J. M. Vergnon, and J. Pourchez, Scientific Reports, 7(2592), 1-7 (2017).
J. S. Stein, M. N. Koffarnus, I. Stepanov, D. K. Hatsukami, and W. K. Bickel, Experimental and Clinical Psychopharmacology, 26(3), 233-243 (2018).
C. O. Cobb, P. S. Hendricks, and T. Eissenberg, BMC Medicine, 13, 119 (2015).
Korea Legislation Research Institute [TOBACCO BUSINESS ACT], https://elaw.klri.re.kr/kor_mobile/viewer.do?hseq=45814&type=part&key=22, Amended by 26 July 2017.
N. Prévôt, De F. Oliveira, S. Perinel-Ragey, T. Basset, J. M. Vergnon, and J. Pourchez, Scientific Reports, 7(2592), 1-7 (2017).
J. S. Stein, M. N. Koffarnus, I. Stepanov, D. K. Hatsukami, and W. K. Bickel, Experimental and Clinical Psychopharmacology, 26(3), 233-243 (2018).
C. O. Cobb, P. S. Hendricks, and T. Eissenberg, BMC Medicine, 13, 119 (2015).
Korea Legislation Research Institute [TOBACCO BUSINESS ACT], https://elaw.klri.re.kr/kor_mobile/viewer.do?hseq=45814&type=part&key=22, Amended by 26 July 2017.
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