지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.8
- 수록면
- 1 - 10 (10page)
- DOI
- 10.1038/s12276-022-00820-1
이용수
초록· 키워드
오류제보하기
Phospholipase D2 (PLD2), a signaling protein, plays a central role in cellular communication and various biological processes. Here, we show that PLD2 contributes to bone homeostasis by regulating bone resorption through osteoclastic cell migration and microtubule-dependent cytoskeletal organization. Pld2-deficient mice exhibited a low bone mass attributed to increased osteoclast function without altered osteoblast activity. While Pld2 deficiency did not affect osteoclast differentiation, its absence promoted the migration of osteoclast lineage cells through a mechanism involving M-CSF-induced activation of the PI3K?Akt?GSK3β signaling pathway. The absence of Pld2 also boosted osteoclast spreading and actin ring formation, resulting in elevated bone resorption. Furthermore, Pld2 deletion increased microtubule acetylation and stability, which were later restored by treatment with a specific inhibitor of Akt, an essential molecule for microtubule stabilization and osteoclast bone resorption activity. Interestingly, PLD2 interacted with the M-CSF receptor (c-Fms) and PI3K, and the association between PLD2 and c-Fms was reduced in response to M-CSF. Altogether, our findings indicate that PLD2 regulates bone homeostasis by modulating osteoclastic cell migration and microtubule stability via the M-CSF-dependent PI3K?Akt?GSK3β axis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase
BMB Reports
2021 .01
-
Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer
Experimental and Molecular Medicine
2022 .09
-
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
Experimental and Molecular Medicine
2021 .09
-
청소년 개인음향기기 이용습관, 청력손실 원인과 청력보호 이해에 관한 실태조사 및 설문지 개발
한국음향학회지
2016 .01
-
Loss of phospholipase D2 impairs VEGF-induced angiogenesis
BMB Reports
2016 .01
-
The M-CSF receptor in osteoclasts and beyond
Experimental and Molecular Medicine
2020 .08
-
Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases
Experimental and Molecular Medicine
2024 .02
-
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
Experimental and Molecular Medicine
2015 .01
-
Remifentanil Negatively Regulates RANKL-Induced Osteoclast Differentiation and Bone Resorption by Inhibiting c-Fos/NFATc1 Expression
조직공학과 재생의학
2018 .01
-
Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
BMB Reports
2018 .01
-
PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways
Experimental and Molecular Medicine
2024 .07
-
Transparent conductive GZO/Ag/GZO films by PLD at Room Temperature
한국신·재생에너지학회 학술대회 초록집
2016 .05
-
Study on Graphene Thin Films Grown on Single Crystal Sapphire Substrates Without a Catalytic Metal Using Pulsed Laser Deposition
Transactions on Electrical and Electronic Materials
2015 .01
-
The estrogen-related receptor γ modulator, GSK5182, inhibits osteoclast differentiation and accelerates osteoclast apoptosis
BMB Reports
2021 .01
-
Functional Development of the Inside of Microtubules Based on a Tau-derived Peptide
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways
BMB Reports
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0