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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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Endocytosis is differentially regulated by hypoxia-inducible factor-1α (HIF-1α) and phospholipase D (PLD). However, the relationship between HIF-1α and PLD in endocytosis is unknown. HIF-1α is degraded through the prolyl hydroxylase (PHD)/von Hippel–Lindau (VHL) ubiquitination pathway in an oxygen-dependent manner. Here, we show that PLD1 recovers the decrease in epidermal growth factor receptor (EGFR) endocytosis induced by HIF-1α independent of lipase activity via the Rab5-mediated endosome fusion pathway. EGF-induced interaction of PLD1 with HIF-1α, PHD and VHL may contribute to EGFR endocytosis. The pleckstrin homology domain (PH) of PLD1 itself promotes degradation of HIF-1α, then accelerates EGFR endocytosis via upregulation of rabaptin-5 and suppresses tumor progression. These findings reveal a novel role of the PLD1-PH domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1α in the EGFR endocytosis pathway.
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참고문헌 (27)
참고문헌 신청
Blume-Jensen P / 2001 / Oncogenic kinase signalling / Nature 411 : 355 ~ 365
Bucci C / 1992 / The small GTPase rab5 functions as regulatory factor in the early endocytic pathway / Cell 70 : 729 ~ 740
Du G / 2004 / Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis / Mol Biol Cell 15 : 1024 ~ 1030
Franovic A / 2007 / Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer / Proc Natl Acad Sci
Harris AL / 2002 / Hypoxia?a key regulatory factor in tumour growth / Nat Rev Cancer 2 : 38 ~ 47
Bucci C / 1992 / The small GTPase rab5 functions as regulatory factor in the early endocytic pathway / Cell 70 : 729 ~ 740
Du G / 2004 / Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis / Mol Biol Cell 15 : 1024 ~ 1030
Franovic A / 2007 / Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer / Proc Natl Acad Sci
Harris AL / 2002 / Hypoxia?a key regulatory factor in tumour growth / Nat Rev Cancer 2 : 38 ~ 47
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